Hypertension-associated cerebral small vessel disease is a common finding in older people.
Strongly associated with age and hypertension, small vessel disease is found at autopsy in …

Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk
factors throughout the life course. However, robust evidence for most of these risk factors is …

Elevated blood pressure is a well-established risk factor for age-related cognitive decline.
Long linked to cognitive impairment on vascular bases, increasing evidence suggests a …

Vascular cognitive impairment (VCI) traditionally encompasses a variety of cerebrovascular
pathologies that contribute to varying levels of cognitive impairment, ranging from subtle to …

Background Evidence exists that lowering high blood pressure reduces the risk of dementia.
However, the generalizability of this evidence to old patients from the general population …

Importance The utility of antihypertensives and ideal blood pressure (BP) for dementia
prevention in late life remains unclear and highly contested. Objectives To assess the …

The burden of neurologic diseases, including stroke and dementia, is expected to grow
substantially in the coming decades. Thus, achieving optimal brain health has been …

Background Growing evidence suggests that Coronary artery disease (CAD) is associated
with cognitive impairment. However, these results from observational studies was not …

The debate over whether lowering blood pressure (BP) measurably decreases the risk of
dementia and cognitive decline still awaits firm conclusions, with pro1, 2 and con3 sides …

BACKGROUND Mid-life hypertension is associated with cognitive decline and dementia in
later life. Reducing high blood pressure (BP) with antihypertensive agents is a well …