The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Pulmonary fibrosis (PF) is characterized by aberrant extracellular matrix (ECM) deposition,
activation of fibroblasts to myofibroblasts and parenchymal disorganization, which have an …

Background: The presence of emphysema is relatively common in patients with fibrotic
interstitial lung disease. This has been designated combined pulmonary fibrosis and …

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the
extracellular matrix and the basement membrane. Thus, these enzymes regulate airway …

Several studies have implicated a causative role for specific matrix metalloproteinases
(MMPs) in the development and progression of cigarette smoke-induced chronic obstructive …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality
globally and the risk of developing lung cancer is six times greater in individuals with COPD …

Remodeling of the extracellular matrix (ECM) is a common feature in lung diseases such as
chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) …

Matrix metalloproteinases (MMPs) play an essential role in various physiological events.
Recent studies have revealed its carcinogenic effect in malignancies. However, the different …

Rationale: ADAM8 (a disintegrin and metalloproteinase domain-8) is expressed by
leukocytes and epithelial cells in health, but its contribution to the pathogenesis of chronic …

Microplastics (MPs) are plastic particles< 5 mm in diameter, of which polystyrene
microplastics (PS-MPs) are representative type. The extracellular matrix (ECM) degradation …