As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …

Although defects in intracellular calcium homeostasis are known to play a role in the
pathogenesis of Parkinson's disease (PD), the underlying molecular mechanisms remain …

The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial
dysfunction has an established and prominent role. This is supported by an already large …

Mitophagy impairment and oxidative stress are cardinal pathological hallmarks in
Parkinson's disease (PD), a common age-related neurodegenerative condition. The specific …

Parkinson's disease (PD) is an advanced neurodegenerative disease (NDD) caused by the
degeneration of dopaminergic neurons (DNs) in the substantia nigra (SN). As PD is an age …

Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …

The progressive reduction of the dopaminergic neurons of the substantia nigra is the
fundamental process underlying Parkinson's disease (PD), while the mechanism of …

Therapeutic advances for neurological disorders are challenging due to limited accessibility
of the human central nervous system and incomplete understanding of disease …