Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Dissections or ruptures of aortic aneurysms remain a leading cause of death in the
developed world, with the majority of deaths being preventable if individuals at risk are …

Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …

Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …

IL6 is a pleiotropic cytokine that is made in response to perturbations in homeostasis. IL6
becomes elevated in the acute response to host injury and can activate immune cells, direct …

Background: Mendelian randomization (MR) studies investigate the effect of genetic
variation in levels of an exposure on an outcome, thereby using genetic variation as an …

Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Inflammation, which is directly regulated by interleukin-6 (IL-6) signaling, is implicated in the
etiology of several chronic diseases. Although a common, non-synonymous variant in the IL …