Synthetic molecular communication (MC) is a new communication engineering paradigm
which is expected to enable revolutionary applications such as smart drug delivery and real …

Background The transport of transepithelial Cl-and HCO3-is crucial for the function of the
intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key …

Extracellular acidification occurs in inflamed tissue and the tumor microenvironment;
however, a systematic study on how pH sensing contributes to tissue homeostasis is lacking …

Neutrophils are the most abundant leukocyte population in the human circulatory system
and are rapidly recruited to sites of inflammation. Neutrophils play a multifaceted role in …

The intestinal mucosa exists in a state of" physiologic hypoxia," where oxygen tensions are
markedly lower than those in other tissues. Intestinal epithelial cells (IECs) have evolved to …

Significance: Chronic diabetic wounds on the lower extremities (diabetic foot ulcers, DFU)
are one of the most prevalent and life-threatening complications of diabetes, responsible for …

Metabolic changes associated with tissue inflammation result in significant extracellular
acidosis (EA). Within mucosal tissues, intestinal epithelial cells (IEC) have evolved adaptive …

Inflammatory bowel disease (IBD) is a family of conditions characterized by chronic,
relapsing inflammation of the gastrointestinal tract. IBD afflicts over 3 million adults in the …

During episodes of acute inflammation, polymorphonuclear leukocytes (PMNs) are actively
recruited to sites of inflammation or injury where they provide anti-microbial and wound …

On the backdrop of all acute inflammatory processes lies the activation of the resolution
response. Recent years have witnessed an emerging interest in defining molecular factors …