Mitochondria-targeted, nanoparticle-based drug-delivery systems: Therapeutics for mitochondrial disorders

S Buchke, M Sharma, A Bora, M Relekar, P Bhanu… - Life, 2022 - mdpi.com
Apart from ATP generation, mitochondria are involved in a wide range of functions, making
them one of the most prominent organelles of the human cell. Mitochondrial dysfunction is …

Structure and function of mitochondria‐associated endoplasmic reticulum membranes (MAMs) and their role in cardiovascular diseases

Y Luan, Y Luan, RX Yuan, Q Feng… - … Medicine and Cellular …, 2021 - Wiley Online Library
Abnormal function of suborganelles such as mitochondria and endoplasmic reticulum often
leads to abnormal function of cardiomyocytes or vascular endothelial cells and …

Cardiovascular inflammaging: mechanisms and translational aspects

ML Barcena, M Aslam, S Pozdniakova, K Norman… - Cells, 2022 - mdpi.com
Aging is one of the major non-reversible risk factors for several chronic diseases, including
cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause …

Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury

G Pedriali, D Ramaccini, E Bouhamida… - Frontiers in Cell and …, 2022 - frontiersin.org
Cardiovascular disease is the most common cause of death worldwide and in particular,
ischemic heart disease holds the most considerable position. Even if it has been deeply …

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

F Alia, M Putri, N Anggraeni… - Frontiers in …, 2022 - frontiersin.org
Cardiac damage and vascular dysfunction due to underlying diseases, such as
hypertension and cardiac thrombosis, or side effects from certain drugs may lead to critical …

Mitochondrial-derived vesicles—link to extracellular vesicles and implications in cardiovascular disease

J Heyn, MA Heuschkel, C Goettsch - International Journal of Molecular …, 2023 - mdpi.com
Mitochondria are dynamic organelles regulating metabolism, cell death, and energy
production. Therefore, maintaining mitochondrial health is critical for cellular homeostasis …

Mitochondrial effects of common cardiovascular medications: the good, the bad and the mixed

AM Bețiu, L Noveanu, IM Hâncu, A Lascu… - International Journal of …, 2022 - mdpi.com
Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

Mitochondria-targeted delivery strategy of dual-loaded liposomes for Alzheimer's disease therapy

L Vasileva, G Gaynanova, F Valeeva… - International Journal of …, 2023 - mdpi.com
Liposomes modified with tetradecyltriphenylphosphonium bromide with dual loading of α-
tocopherol and donepezil hydrochloride were successfully designed for intranasal …

Nanosystems in cardiovascular medicine: advancements, applications, and future perspectives

H Omidian, N Babanejad, LX Cubeddu - Pharmaceutics, 2023 - mdpi.com
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality globally.
Despite significant advancements in the development of pharmacological therapies, the …

[HTML][HTML] Therapeutic effects of the combination of moderate-intensity endurance training and MitoQ supplementation in rats with isoproterenol-induced myocardial …

F Rostamzadeh, H Najafipour, S Aminizadeh… - Biomedicine & …, 2024 - Elsevier
Introduction Mitochondrial dysfunction causes myocardial disease. This study investigated
the effects of MitoQ alone and in combination with moderate-intensity endurance training …