Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a
common feature of all cancers, requires fatty acids for synthesis of membranes and signaling …

Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the
homeostatic control of almost all biological processes. Their direct mode of ligand regulation …

As plant-derived natural products, saponins have been widely applied for the dietary
modification of metabolic syndrome. However, the underlying mechanisms of their …

Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry
out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors …

Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de
novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor
properties. Here, we explored its efficacy and mechanism of cell death in melanoma and …

The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for
Alzheimer's disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a …

Liver X receptors (LXRs) have been increasingly recognized as a potential therapeutic
target to treat pathological conditions ranging from vascular and metabolic diseases …

The function of ATP binding cassette protein A1 (ABCA1) is central to cholesterol
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …