Cellular fatty acid metabolism and cancer
Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a
common feature of all cancers, requires fatty acids for synthesis of membranes and signaling …
common feature of all cancers, requires fatty acids for synthesis of membranes and signaling …
Liver X receptor biology and pharmacology: new pathways, challenges and opportunities
T Jakobsson, E Treuter, JÅ Gustafsson… - Trends in …, 2012 - cell.com
Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the
homeostatic control of almost all biological processes. Their direct mode of ligand regulation …
homeostatic control of almost all biological processes. Their direct mode of ligand regulation …
Saponins as modulators of nuclear receptors
T Zhang, S Zhong, T Li, J Zhang - Critical reviews in food science …, 2020 - Taylor & Francis
As plant-derived natural products, saponins have been widely applied for the dietary
modification of metabolic syndrome. However, the underlying mechanisms of their …
modification of metabolic syndrome. However, the underlying mechanisms of their …
Targeting liver X receptors in cancer therapeutics
CY Lin, JÅ Gustafsson - Nature Reviews Cancer, 2015 - nature.com
Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry
out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors …
out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors …
Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis
Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de
novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The …
novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The …
Targeting nuclear receptors in neurodegeneration and neuroinflammation
S Willems, D Zaienne, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …
expression upon ligand signals and present as attractive therapeutic targets especially in …
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor
properties. Here, we explored its efficacy and mechanism of cell death in melanoma and …
properties. Here, we explored its efficacy and mechanism of cell death in melanoma and …
Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk
The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for
Alzheimer's disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a …
Alzheimer's disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a …
Ligands of therapeutic utility for the liver X receptors
Liver X receptors (LXRs) have been increasingly recognized as a potential therapeutic
target to treat pathological conditions ranging from vascular and metabolic diseases …
target to treat pathological conditions ranging from vascular and metabolic diseases …
[HTML][HTML] Remembering your A, B, C's: Alzheimer's disease and ABCA1
CT Lewandowski, MS Laham, GRJ Thatcher - Acta Pharmaceutica Sinica B, 2022 - Elsevier
The function of ATP binding cassette protein A1 (ABCA1) is central to cholesterol
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …