Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Zinc is the second abundant trace element in the human central nervous system (CNS). Zinc
homeostasis is impaired in the elderly population and Alzheimer's disease (AD) patients …

Isothermal titration calorimetry is a widely used biophysical technique for studying the
formation or dissociation of molecular complexes. Over the last 5 years, much work has …

The Zn (II) ion has been linked to Alzheimer's disease (AD) due to its ability to modulate the
aggregating properties of the amyloid-β (Aβ) peptide, where Aβ aggregation is a central …

Conformational changes of Aβ peptide result in its transformation from native monomeric
state to the toxic soluble dimers, oligomers and insoluble aggregates that are hallmarks of …

Aggregation of TDP-43 (transactive response DNA binding protein 43 kDa) is a hallmark of
certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …

Drug development for the treatment of Alzheimer's disease (AD) has been for a long time
focused on agents that were expected to support endogenous β-amyloid (Aβ) in a …

Tau is an intrinsically disordered microtubule-associated protein that is implicated in several
neurodegenerative disorders called tauopathies. In these diseases, Tau is found in the form …

The direct electrochemical oxidation of synthetic peptides analogous to the amyloid-beta
(Aβ) implicated in the pathogenesis of Alzheimer's disease has been demonstrated on …