Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance
E Atrián-Blasco, P Gonzalez, A Santoro, B Alies… - Coordination chemistry …, 2018 - Elsevier
Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …
their development. This is the case of important neurodegenerative diseases such as …
Alzheimer's disease: How metal ions define β-amyloid function
KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
Multifunctional roles of zinc in Alzheimer's disease
Z Xie, H Wu, J Zhao - Neurotoxicology, 2020 - Elsevier
Zinc is the second abundant trace element in the human central nervous system (CNS). Zinc
homeostasis is impaired in the elderly population and Alzheimer's disease (AD) patients …
homeostasis is impaired in the elderly population and Alzheimer's disease (AD) patients …
Applications of isothermal titration calorimetry–the research and technical developments from 2011 to 2015
RJ Falconer - Journal of Molecular Recognition, 2016 - Wiley Online Library
Isothermal titration calorimetry is a widely used biophysical technique for studying the
formation or dissociation of molecular complexes. Over the last 5 years, much work has …
formation or dissociation of molecular complexes. Over the last 5 years, much work has …
Zinc (II) binding site to the amyloid-β peptide: insights from spectroscopic studies with a wide series of modified peptides
The Zn (II) ion has been linked to Alzheimer's disease (AD) due to its ability to modulate the
aggregating properties of the amyloid-β (Aβ) peptide, where Aβ aggregation is a central …
aggregating properties of the amyloid-β (Aβ) peptide, where Aβ aggregation is a central …
Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization
Conformational changes of Aβ peptide result in its transformation from native monomeric
state to the toxic soluble dimers, oligomers and insoluble aggregates that are hallmarks of …
state to the toxic soluble dimers, oligomers and insoluble aggregates that are hallmarks of …
Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates
Aggregation of TDP-43 (transactive response DNA binding protein 43 kDa) is a hallmark of
certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …
certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …
Anti-amyloid therapy of Alzheimer's disease: current state and prospects
Drug development for the treatment of Alzheimer's disease (AD) has been for a long time
focused on agents that were expected to support endogenous β-amyloid (Aβ) in a …
focused on agents that were expected to support endogenous β-amyloid (Aβ) in a …
Zinc induces temperature-dependent reversible self-assembly of tau
Tau is an intrinsically disordered microtubule-associated protein that is implicated in several
neurodegenerative disorders called tauopathies. In these diseases, Tau is found in the form …
neurodegenerative disorders called tauopathies. In these diseases, Tau is found in the form …
Direct electrochemical oxidation of amyloid-β peptides via tyrosine, histidine, and methionine residues
EV Suprun, SA Khmeleva, SP Radko, SA Kozin… - Electrochemistry …, 2016 - Elsevier
The direct electrochemical oxidation of synthetic peptides analogous to the amyloid-beta
(Aβ) implicated in the pathogenesis of Alzheimer's disease has been demonstrated on …
(Aβ) implicated in the pathogenesis of Alzheimer's disease has been demonstrated on …