Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …

The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Background Recent research on the implications of gut microbiota on brain functions has
helped to gather important information on the relationship between them. Pathogenesis of …

Drug delivery to the brain is limited by poor penetration of pharmaceutical agents across the
blood-brain barrier (BBB), within the brain parenchyma, and into specific cells of interest …

Acute central nervous system injuries (ACNSI), encompassing traumatic brain injury (TBI),
non-traumatic brain injury like stroke and encephalomeningitis, as well as spinal cord …

Polymeric nanoparticles provide a non-invasive strategy for enhancing the delivery of labile
hydrophilic enzymatic cargo for neurological disease applications. One of the most common …

Cerebral ischemia is a major cause of death in both neonates and adults, and currently has
no cure. Nanotechnology represents one promising area of therapeutic development for …

Kynurenic acid (KYNA), a tryptophan metabolite, is believed to exert neuromodulatory and
neuroprotective effects in the brain. This study aimed to examine KYNA's capacity to modify …

Neurodegenerative disorders of the central nervous system (CNS) and brain traumatic
insults are characterized by complex overlapping pathophysiological alterations …

Hypoxic-Ischemic Encephalopathy (HIE) in the brain is the leading cause of morbidity and
mortality in neonates and can lead to irreparable tissue damage and cognition. Thus …