[HTML][HTML] Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic …

GD Pule, S Mowla, N Novitzky, A Wonkam - Clinical and translational …, 2016 - Springer
Background The major therapeutic benefit of hydroxyurea, the only FDA-approved
pharmacologic treatment for sickle cell disease (SCD), is directly related to fetal hemoglobin …

[HTML][HTML] In Vitro and In Vivo Studies for the Investigation of γ-Globin Gene Induction by Adhatoda vasica: A Pre-Clinical Study of HbF Inducers for β-Thalassemia

F Iftikhar, S Rahman, MBN Khan, K Khan… - Frontiers in …, 2022 - frontiersin.org
Fetal hemoglobin (HbF) is a potent genetic modifier, and the γ-globin gene induction has
proven to be a sustainable therapeutic approach for the management of β-thalassemia. In …

Multidimensional plasma lipid composition and its causal association with type 2 diabetes mellitus: A Mendelian randomization study

Y Zhang, Y Ni, H An, L Li, Y Ren - Nutrition, Metabolism and Cardiovascular …, 2024 - Elsevier
Background and aim Recent research extends our knowledge of plasma lipid species,
building on established links between serum lipid levels and Type 2 Diabetes Mellitus …

[PDF][PDF] Phytochemical, pharmacological and GC-MS characterization of the lipophilic fraction of monotheca buxifolia.

S Javed, A Shoaib, Z Mahmood, S Nawaz, KM Khan - 2021 - asianjab.com
Abstract Monotheca buxifolia [(Falc.) A. DC.] indigenous to northern Pakistan is a broad-
leaved evergreen traditional plant of pharmacological versatility. The present investigation …

Study of the chemical composition and anesthetic effect of Cladophora glomerata extract on the physiological and hematological aspects of Biomphalaria alexandrina …

SM Mansour, EA Morsi, AS Mohamed… - Egyptian Journal of …, 2024 - journals.ekb.eg
Algae produce numerous biologically active substances, some of which could be turned into
brand-new medications. Thus, the current work utilized Biomphalaria alexandrina snails as …

Analysis of the Secondary Metabolites of Indigofera Aspalathoides DC Oil to Control Various Human Ailments

AV Gopalakrishnan, N Krishnan, PK Singh… - … Protein Targets for …, 2023 - World Scientific
About 60% of the world population, the rural population of the developing countries,
including the developed countries where there is a domination of modern medicines, uses …

Identification of Bioactive Compounds in Chrysobalanus icaco Seed Kernel Using Gas Chromatography-Mass Spectrometry

NC Oganezi, T Agbaeze, SO Kalu - American Journal of Food …, 2024 - journals.e-palli.com
Chrysobalanus icaco seed kernel (ie Cocoplum) is good source of oil and is utilized as spice
in soups or stews in some African cuisines. The work aimed to identify compounds in …

12 Analysis of the Secondary

DC Aspalathoides, VH Ailments - Therapeutic Protein Targets …, 2022 - books.google.com
About 60% of the world population, the rural population of the developing countries,
including the developed countries where there is a domination of modern medicines, uses …

[PDF][PDF] In Vitro and In Vivo Studies for the Investigation of γ-Globin Gene

F Iftikhar, S Rahman, MBN Khan, K Khan, MN Khan… - academia.edu
A. vasica (100mg/kg) showed significant induction of the γ-globin gene and HbF production.
While in the acute study, the hematological and biochemical indices were found to be …

[PDF][PDF] AJAB

S Javed, A Shoaib, A Malik, B Ijaz… - Asian J Agric & …, 2021 - classical.goforpromo.com
Abstract Monotheca buxifolia [(Falc.) A. DC.] indigenous to northern Pakistan is a broad-
leaved evergreen traditional plant of pharmacological versatility. The present investigation …