Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

With the development of NMR methodology and technology during the past decades, solid-
state NMR (ssNMR) has become a particularly important tool for investigating structure and …

One of the main research topics related to Alzheimer's disease is the aggregation of the
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

In Alzheimer's disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …

The mechanisms behind the Amyloid-β (Aβ) peptide neurotoxicity in Alzheimer's disease are
intensely studied and under debate. One suggested mechanism is that the peptides …

Rutin (quercetin-3-O-rutinoside) is a multifunctional natural flavonoid glycoside with
profound effects on the various cellular functions under pathological conditions. Due to the …

Fibrillary aggregates of amyloid-β (Aβ) are the pathological hallmark of Alzheimer's disease
(AD). Clearing Aβ deposition or inhibiting Aβ aggregation is a promising approach to treat …