The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

The reception and integration of the plethora of signals a cell receives from its
microenvironment determines the cell's fate. CD44 functions as a receptor for hyaluronan …

The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …

CD44 is a cell surface HA‐binding glycoprotein that is overexpressed to some extent by
almost all tumors of epithelial origin and plays an important role in tumor initiation and …

Helicobacter pylori causes persistent infection in the gastric epithelium of more than half of
the world's population, leading to the development of severe complications such as peptic …

Highlights•CD44 receptor is overexpressed in highly invasive stem-like cancer cells
(SLCS).•CD44 receptors have high affinity toward hyaluronic acid (HA) binding.•Recent …

Cancer stem cells (CSCs) represent a unique subpopulation of self-renewing oncogenic
cells that drive cancer initiation and progression. CSCs often acquire multidrug and …

Objective Gastric cancer (GC) is a leading cause of cancer-related mortality. Although
microbes besides Helicobacter pylori may also contribute to gastric carcinogenesis, wild …

The surface marker CD44 has been identified as one of several markers associated with
cancer stem cells (CSC) in solid tumors, but its ubiquitous expression in many cell types …