Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

Polysaccharide based nanogels in the drug delivery system: Application as the carrier of pharmaceutical agents

TA Debele, SL Mekuria, HC Tsai - Materials Science and Engineering: C, 2016 - Elsevier
Polysaccharide-based nanoparticles have fascinated attention as a vesicle of different
pharmaceutical agents due to their unique multi-functional groups in addition to their …

Micelles with ultralow critical micelle concentration as carriers for drug delivery

Y Lu, Z Yue, J Xie, W Wang, H Zhu, E Zhang… - Nature biomedical …, 2018 - nature.com
Conventional micellar carriers disassemble into free surfactants when diluted at
concentrations below the critical micelle concentration (CMC). This limits the bioavailability …

Micellar nanocarriers: pharmaceutical perspectives

VP Torchilin - Pharmaceutical research, 2007 - Springer
Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and
hydrophilic shell are currently successfully used as pharmaceutical carriers for water …

Structure and design of polymeric surfactant-based drug delivery systems

VP Torchilin - Journal of controlled release, 2001 - Elsevier
The review concentrates on the use of polymeric micelles as pharmaceutical carriers.
Micellization of biologically active substances is a general phenomenon that increases the …

Amphiphilic block copolymers for drug delivery

ML Adams, A Lavasanifar, GS Kwon - Journal of pharmaceutical sciences, 2003 - Elsevier
Amphiphilic block copolymers (ABCs) have been used extensively in pharmaceutical
applications ranging from sustained-release technologies to gene delivery. The utility of …

Passive and active drug targeting: drug delivery to tumors as an example

VP Torchilin - Drug delivery, 2010 - Springer
The paradigm of using nanoparticulate pharmaceutical carriers has been well established
over the past decade, both in pharmaceutical research and in the clinical setting. Drug …

Biodegradable polymeric scaffolds for musculoskeletal tissue engineering

CM Agrawal, RB Ray - … Research: An Official Journal of The …, 2001 - Wiley Online Library
Biodegradable scaffolds have played an important role in a number of tissue engineering
attempts over the past decade. The goal of this review article is to provide a brief overview of …

Nano-engineering block copolymer aggregates for drug delivery

C Allen, D Maysinger, A Eisenberg - Colloids and Surfaces B: Biointerfaces, 1999 - Elsevier
This review describes the properties of block copolymer micelles which influence their
efficiency as drug delivery vehicles for hydrophobic drugs. The key performance related …

Fabrication of micellar nanoparticles for drug delivery through the self-assembly of block copolymers

ZL Tyrrell, Y Shen, M Radosz - Progress in Polymer Science, 2010 - Elsevier
Micelles formed through the self-assembly of block copolymers have been widely used to
encapsulate highly hydrophobic drugs to increase their effective solubility. However, this …