Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
DC Fingar, J Blenis - Oncogene, 2004 - nature.com
Cell growth (an increase in cell mass and size through macromolecular biosynthesis) and
cell cycle progression are generally tightly coupled, allowing cells to proliferate continuously …
cell cycle progression are generally tightly coupled, allowing cells to proliferate continuously …
[HTML][HTML] The TOR pathway: a target for cancer therapy
MA Bjornsti, PJ Houghton - Nature Reviews Cancer, 2004 - nature.com
Rapamycin, a macrocyclic lactone, is a highly specific inhibitor of the serine/threonine
protein kinase target of rapamycin (TOR). Although it is clear that TOR controls initiation of …
protein kinase target of rapamycin (TOR). Although it is clear that TOR controls initiation of …
[HTML][HTML] mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
The nutrient-and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates
many processes that control growth, including protein synthesis, autophagy, and …
many processes that control growth, including protein synthesis, autophagy, and …
[HTML][HTML] Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
K Hara, Y Maruki, X Long, K Yoshino, N Oshiro… - Cell, 2002 - cell.com
Abstract mTOR controls cell growth, in part by regulating p70 S6 kinase α (p70α) and
eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding …
eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding …
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
ME Feldman, B Apsel, A Uotila, R Loewith… - PLoS …, 2009 - journals.plos.org
The mammalian target of rapamycin (mTOR) regulates cell growth and survival by
integrating nutrient and hormonal signals. These signaling functions are distributed between …
integrating nutrient and hormonal signals. These signaling functions are distributed between …
Regulation of translation initiation by FRAP/mTOR
Regulation of protein synthesis in eukaryotes plays a critical role in development,
differentiation, cell cycle progression, cell growth, and apoptosis (Mathews et al. 2000) …
differentiation, cell cycle progression, cell growth, and apoptosis (Mathews et al. 2000) …
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
In most instances, translation is regulated at the initiation phase, when a ribosome is
recruited to the 5′ end of an mRNA. The eIF4E-binding proteins (4E-BPs) interdict …
recruited to the 5′ end of an mRNA. The eIF4E-binding proteins (4E-BPs) interdict …
[HTML][HTML] Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase
Elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2. Insulin induces
dephosphorylation of eEF2 and inactivation of eEF2 kinase, and these effects are blocked …
dephosphorylation of eEF2 and inactivation of eEF2 kinase, and these effects are blocked …
[HTML][HTML] TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
SS Schalm, DC Fingar, DM Sabatini, J Blenis - Current biology, 2003 - cell.com
Background: The mammalian target of rapamycin, mTOR, is a serine/threonine kinase that
controls cell growth and proliferation via the translation regulators eukaryotic initiation factor …
controls cell growth and proliferation via the translation regulators eukaryotic initiation factor …
Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with …
Purpose Everolimus is a selective mammalian target of rapamycin (mTOR) inhibitor with
promising anticancer activity. In order to identify a rationally based dose and schedule for …
promising anticancer activity. In order to identify a rationally based dose and schedule for …