[HTML][HTML] The Nuclear NF-κB Regulator IκBζ: Updates on Its Molecular Functions and Pathophysiological Roles

S Yamazaki - Cells, 2024 - mdpi.com
More than a decade after the discovery of the classical cytoplasmic IκB proteins, IκBζ was
identified as an additional member of the IκB family. Unlike cytoplasmic IκB proteins, IκBζ …

4D-DIA-based Proteomics Analysis Reveals the Protective Effects of Pidanjiangtang Granules in IGT Rat Model

Y Xie, Y Fan, X Liu, Z Li, S Liu - Journal of Ethnopharmacology, 2024 - Elsevier
Abstract Ethnopharmacological relevance The Pidanjiangtang (PDJT) formula was founded
on the" Pidan" theory from the" Nei Jing." PDJT is considered to eliminate the accumulation …

Constitutive expression of IκBζ promotes tumor growth and immunotherapy resistance in melanoma

A Kolb, AM Kulis-Mandic, M Klein, A Stastny, M Haist… - bioRxiv, 2024 - biorxiv.org
Background: IκBζ, a rather unknown co-regulator of NF-κB, is mostly inducibly expressed
and can either activate or repress a specific subset of NF-κB target genes. While its role as a …

OCA-B promotes autoimmune demyelination through control of stem-like CD4+ T cells

EP Hughes, AR Syage, EM Mehrabad, TE Lane… - bioRxiv, 2023 - biorxiv.org
Stem-like T cell populations can selectively contribute to autoimmunity, but the activities that
promote and sustain these populations are incompletely understood. Here, we show that T …