Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - Elsevier
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

Betaine in inflammation: mechanistic aspects and applications

G Zhao, F He, C Wu, P Li, N Li, J Deng, G Zhu… - Frontiers in …, 2018 - frontiersin.org
Betaine is known as trimethylglycine and is widely distributed in animals, plants, and
microorganisms. Betaine is known to function physiologically as an important …

[HTML][HTML] Betaine in human nutrition

SAS Craig - The American journal of clinical nutrition, 2004 - Elsevier
Betaine is distributed widely in animals, plants, and microorganisms, and rich dietary
sources include seafood, especially marine invertebrates (≈ 1%); wheat germ or bran (≈ …

The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism

M Lever, S Slow - Clinical biochemistry, 2010 - Elsevier
Betaine is an essential osmolyte and source of methyl groups and comes from either the diet
or by the oxidation of choline. Its metabolism methylates homocysteine to methionine, also …

Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study

M Lever, PM George, S Slow, D Bellamy, JM Young… - PloS one, 2014 - journals.plos.org
Background Betaine is a major osmolyte, also important in methyl group metabolism.
Concentrations of betaine, its metabolite dimethylglycine and analog trimethylamine-N …

Betaine: a key modulator of one-carbon metabolism and homocysteine status

PM Ueland, PI Holm, S Hustad - Clinical Chemistry and Laboratory …, 2005 - degruyter.com
Betaine serves as a methyl donor in a reaction converting homocysteine to methionine,
catalysed by the enzyme betaine-homocysteine methyltransferase. It has been used for …

Glycine betaine and glycine betaine analogues in common foods

FJ De Zwart, S Slow, RJ Payne, M Lever, PM George… - Food chemistry, 2003 - Elsevier
In this study we have surveyed the betaine content of a wide range of foods commonly found
in the western diet. Glycine betaine, proline betaine (stachydrine), trigonelline and …

A review of pharmacological and pharmacokinetic properties of stachydrine

F Cheng, Y Zhou, M Wang, C Guo, Z Cao… - Pharmacological …, 2020 - Elsevier
Stachydrine is extracted from the leaves of Leonurus japonicus Houtt (or Motherwort,“Yi Mu
Cao” in Traditional Chinese Medicine) and is the major bioactive ingredient. So far …

Metabolic biomarkers of prenatal disorders: an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma

SO Diaz, J Pinto, G Graca, IF Duarte… - Journal of proteome …, 2011 - ACS Publications
This work describes an exploratory NMR metabonomic study of second trimester maternal
urine and plasma, in an attempt to characterize the metabolic changes underlying prenatal …

Urinary biomarkers involved in type 2 diabetes: a review

A Matheson, MDP Willcox, J Flanagan… - … research and reviews, 2010 - Wiley Online Library
Diabetes mellitus is one of the most challenging health concerns of the 21st century. With at
least 30% of the diabetic population remaining undiagnosed, effective and early diagnosis is …