This review uses the National Cancer Institute (NCI) COMPARE program to establish an
extensive list of heterocyclic iminoquinones and quinones with similarities in differential …

Background The mitogen‐activated protein kinase (MAPK) pathway is highly associated
with the progression and metastasis of various solid tumours. MAPK14, a core molecule of …

Herein, two series of tryptanthrin derivatives with benzenesulfonamide substituents were
designed and synthesized to discover novel anti-inflammatory agents. The anti-inflammatory …

The purpose of this review is to underline the protein kinases that have been established,
either in fundamental approach or clinical trials, as potential biological targets in pain …

Background Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-
metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive …

Background Owing to the complex pathophysiological features and heterogeneity of sepsis,
current diagnostic methods are not sufficiently precise or timely, causing a delay in …

Objectives Assisted reproductive technology (ART) is an important part of reproductive
medicine, whose possible effects on offspring's health have drawn widespread attention in …

Objective: Colon cancer is a malignant neoplastic disease that seriously endangers the
health of patients. Pulsatilla decoction (PD) has some therapeutic effects on colon cancer …

Mercuric chloride (HgCl2) is a heavy metal that is toxic to the human body. Carvacrol (CAR)
is a flavonoid found naturally in plants and has many biological and pharmacological …

Abstract p38α is a mitogen-activated protein kinase (MAPK), and the signaling pathways
involved are closely related to the inflammation, apoptosis and differentiation of cells, which …