The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …

Photodynamic therapy (PDT) has emerged as a promising alternative to conventional
cancer therapies such as surgery, chemotherapy, and radiotherapy. PDT comprises the …

Kinase inhibitors have limited success in cancer treatment because tumors circumvent their
action. Using a quantitative proteomics approach, we assessed kinome activity in response …

Photoaffinity labeling (PAL) is a powerful technique in chemical biology and chemical
proteomics, and has been successfully demonstrated on a variety of non-covalent molecular …

Passive immunization against β-amyloid (Aβ) has become an increasingly desirable
strategy as a therapeutic treatment for Alzheimer's disease (AD). However, traditional …

The mammalian response to stress is complex, often involving multiple signalling pathways
that act in concert to influence cell fate. To examine potential interactions between the …

The incidence of non-melanoma skin cancer is rising and primary prevention, including the
use of sun screens, has proven inadequate in reducing this incidence. Chemoprevention …

A simple highly versatile and efficient synthesis of 2, 4, 5-trisubstituted imidazoles is
achieved by three-component cyclocondensation of 1, 2-dicarbonyl compound, aldehyde …

The site of action of a series of pyridinyl imidazole compounds that are selective inhibitors of
p38 mitogen-activated protein kinase in vitro and block proinflammatory cytokine production …

Despite considerable amount of research, the poor prognosis of patients diagnosed with
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …