Glutamine: metabolism and immune function, supplementation and clinical translation
Glutamine is the most abundant and versatile amino acid in the body. In health and disease,
the rate of glutamine consumption by immune cells is similar or greater than glucose. For …
the rate of glutamine consumption by immune cells is similar or greater than glucose. For …
The Warburg effect 97 years after its discovery
RM Pascale, DF Calvisi, MM Simile, CF Feo, F Feo - Cancers, 2020 - mdpi.com
Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …
From Krebs to clinic: glutamine metabolism to cancer therapy
The resurgence of research into cancer metabolism has recently broadened interests
beyond glucose and the Warburg effect to other nutrients, including glutamine. Because …
beyond glucose and the Warburg effect to other nutrients, including glutamine. Because …
Emerging applications of metabolomics in drug discovery and precision medicine
DS Wishart - Nature reviews Drug discovery, 2016 - nature.com
Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
Imaging correlates of adult glioma genotypes
M Smits, MJ van den Bent - Radiology, 2017 - pubs.rsna.org
Primary brain tumors, most commonly gliomas, are histopathologically typed and graded as
World Health Organization (WHO) grades I–IV according to increasing degrees of …
World Health Organization (WHO) grades I–IV according to increasing degrees of …
Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH …
C Choi, JM Raisanen, SK Ganji, S Zhang… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Proton magnetic resonance spectroscopy (MRS) of the brain can detect 2-
hydroxyglutarate (2HG), the oncometabolite produced in neoplasms harboring a mutation in …
hydroxyglutarate (2HG), the oncometabolite produced in neoplasms harboring a mutation in …
2-Hydroxyglutarate MR spectroscopy for prediction of isocitrate dehydrogenase mutant glioma: a systemic review and meta-analysis using individual patient data
CH Suh, HS Kim, SC Jung, CG Choi, SJ Kim - Neuro-oncology, 2018 - academic.oup.com
Background Noninvasive and accurate modality to predict isocitrate dehydrogenase (IDH)
mutant glioma may have great potential in routine clinical practice. We aimed to investigate …
mutant glioma may have great potential in routine clinical practice. We aimed to investigate …
IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
JL Izquierdo-Garcia, P Viswanath, P Eriksson, L Cai… - Cancer research, 2015 - AACR
Abstract Mutant isocitrate dehydrogenase 1 (IDH1) catalyzes the production of 2-
hydroxyglutarate but also elicits additional metabolic changes. Levels of both glutamate and …
hydroxyglutarate but also elicits additional metabolic changes. Levels of both glutamate and …
Isocitrate dehydrogenase mutations in glioma: genetics, biochemistry, and clinical indications
Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade glioma
and secondary glioblastomas. IDH mutants confer a neomorphic enzyme activity that …
and secondary glioblastomas. IDH mutants confer a neomorphic enzyme activity that …
Noninvasive assessment of isocitrate dehydrogenase mutation status in cerebral gliomas by magnetic resonance spectroscopy in a clinical setting
OBJECTIVE Mutations in the isocitrate dehydrogenase (IDH) genes are of proven diagnostic
and prognostic significance for cerebral gliomas. The objective of this study was to evaluate …
and prognostic significance for cerebral gliomas. The objective of this study was to evaluate …