International union of basic and clinical pharmacology. CXI. Pharmacology, signaling, and physiology of metabotropic glutamate receptors
KJ Gregory, C Goudet - Pharmacological reviews, 2021 - ASPET
Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …
Reinforcement learning detuned in addiction: integrative and translational approaches
Suboptimal decision-making strategies have been proposed to contribute to the
pathophysiology of addiction. Decision-making, however, arises from a collection of …
pathophysiology of addiction. Decision-making, however, arises from a collection of …
Metabotropic glutamate receptors as emerging targets for the treatment of schizophrenia
Accumulating evidence of glutamatergic abnormalities in the brains of schizophrenia
patients has led to efforts to target various components of glutamatergic signaling as …
patients has led to efforts to target various components of glutamatergic signaling as …
Touchscreen cognitive testing: Cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease
Translating results from pre-clinical animal studies to successful human clinical trials in
neurodegenerative and neuropsychiatric disease presents a significant challenge. While …
neurodegenerative and neuropsychiatric disease presents a significant challenge. While …
The role of glutamate receptors in attention‐deficit/hyperactivity disorder: From physiology to disease
X Huang, M Wang, Q Zhang, X Chen… - American Journal of …, 2019 - Wiley Online Library
Attention‐deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in
children and adolescents, which is characterized by behavioral problems such as attention …
children and adolescents, which is characterized by behavioral problems such as attention …
Microbiome profiling reveals gut dysbiosis in the metabotropic glutamate receptor 5 knockout mouse model of schizophrenia
Schizophrenia (SZ) is a psychiatric disorder that constitutes one of the top 10 global causes
of disability. More recently, a potential pathogenic role for the gut microbial community …
of disability. More recently, a potential pathogenic role for the gut microbial community …
Chronic voluntary alcohol consumption causes persistent cognitive deficits and cortical cell loss in a rodent model
Chronic alcohol use is associated with cognitive decline that impedes behavioral change
during rehabilitation. Despite this, addiction therapy does not address cognitive deficits, and …
during rehabilitation. Despite this, addiction therapy does not address cognitive deficits, and …
[HTML][HTML] Reduced exploratory behavior in neuronal nucleoredoxin knockout mice
BN Tran, L Valek, A Wilken-Schmitz, DC Fuhrmann… - Redox biology, 2021 - Elsevier
Nucleoredoxin is a thioredoxin-like redoxin that has been recognized as redox modulator of
WNT signaling. Using a Yeast-2-Hybrid screen, we identified calcium calmodulin kinase 2a …
WNT signaling. Using a Yeast-2-Hybrid screen, we identified calcium calmodulin kinase 2a …
Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2
C Fischer, H Endle, L Schumann… - Cellular and molecular …, 2021 - Springer
Recent studies suggest that synaptic lysophosphatidic acids (LPAs) augment glutamate-
dependent cortical excitability and sensory information processing in mice and humans via …
dependent cortical excitability and sensory information processing in mice and humans via …
Targeting vesicular glutamate transporter machinery: implications on metabotropic glutamate receptor 5 signaling and behavior
Cross talk between both pre-and postsynaptic components of glutamatergic
neurotransmission plays a crucial role in orchestrating a multitude of brain functions …
neurotransmission plays a crucial role in orchestrating a multitude of brain functions …