International union of basic and clinical pharmacology. CXI. Pharmacology, signaling, and physiology of metabotropic glutamate receptors

KJ Gregory, C Goudet - Pharmacological reviews, 2021 - ASPET
Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

Reinforcement learning detuned in addiction: integrative and translational approaches

SM Groman, SL Thompson, D Lee, JR Taylor - Trends in neurosciences, 2022 - cell.com
Suboptimal decision-making strategies have been proposed to contribute to the
pathophysiology of addiction. Decision-making, however, arises from a collection of …

Metabotropic glutamate receptors as emerging targets for the treatment of schizophrenia

S Dogra, PJ Conn - Molecular pharmacology, 2022 - ASPET
Accumulating evidence of glutamatergic abnormalities in the brains of schizophrenia
patients has led to efforts to target various components of glutamatergic signaling as …

Touchscreen cognitive testing: Cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease

D Palmer, JR Dumont, TD Dexter, MAM Prado… - … of Learning and …, 2021 - Elsevier
Translating results from pre-clinical animal studies to successful human clinical trials in
neurodegenerative and neuropsychiatric disease presents a significant challenge. While …

The role of glutamate receptors in attention‐deficit/hyperactivity disorder: From physiology to disease

X Huang, M Wang, Q Zhang, X Chen… - American Journal of …, 2019 - Wiley Online Library
Attention‐deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in
children and adolescents, which is characterized by behavioral problems such as attention …

Microbiome profiling reveals gut dysbiosis in the metabotropic glutamate receptor 5 knockout mouse model of schizophrenia

C Gubert, G Kong, V Uzungil… - Frontiers in Cell and …, 2020 - frontiersin.org
Schizophrenia (SZ) is a psychiatric disorder that constitutes one of the top 10 global causes
of disability. More recently, a potential pathogenic role for the gut microbial community …

Chronic voluntary alcohol consumption causes persistent cognitive deficits and cortical cell loss in a rodent model

AJ Charlton, C May, SJ Luikinga, EL Burrows… - Scientific reports, 2019 - nature.com
Chronic alcohol use is associated with cognitive decline that impedes behavioral change
during rehabilitation. Despite this, addiction therapy does not address cognitive deficits, and …

[HTML][HTML] Reduced exploratory behavior in neuronal nucleoredoxin knockout mice

BN Tran, L Valek, A Wilken-Schmitz, DC Fuhrmann… - Redox biology, 2021 - Elsevier
Nucleoredoxin is a thioredoxin-like redoxin that has been recognized as redox modulator of
WNT signaling. Using a Yeast-2-Hybrid screen, we identified calcium calmodulin kinase 2a …

Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2

C Fischer, H Endle, L Schumann… - Cellular and molecular …, 2021 - Springer
Recent studies suggest that synaptic lysophosphatidic acids (LPAs) augment glutamate-
dependent cortical excitability and sensory information processing in mice and humans via …

Targeting vesicular glutamate transporter machinery: implications on metabotropic glutamate receptor 5 signaling and behavior

KS Ibrahim, KS Abd-Elrahman, S El Mestikawy… - Molecular …, 2020 - ASPET
Cross talk between both pre-and postsynaptic components of glutamatergic
neurotransmission plays a crucial role in orchestrating a multitude of brain functions …