[HTML][HTML] A systematic review of the evidence for deprescribing interventions among older people living with frailty

K Ibrahim, NJ Cox, JM Stevenson, S Lim, SDS Fraser… - BMC geriatrics, 2021 - Springer
Background Older people living with frailty are often exposed to polypharmacy and potential
harm from medications. Targeted deprescribing in this population represents an important …

Model-informed precision dosing: background, requirements, validation, implementation, and forward trajectory of individualizing drug therapy

AS Darwich, TM Polasek, JK Aronson… - Annual review of …, 2021 - annualreviews.org
Model-informed precision dosing (MIPD) has become synonymous with modern approaches
for individualizing drug therapy, in which the characteristics of each patient are considered …

Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes

D Gnjidic, SN Hilmer, FM Blyth, V Naganathan… - Journal of clinical …, 2012 - Elsevier
OBJECTIVE: This study aimed to determine an optimal discriminating number of
concomitant medications associated with geriatric syndromes, functional outcomes, and …

Too much medicine in older people? Deprescribing through shared decision making

J Jansen, V Naganathan, SM Carter, AJ McLachlan… - Bmj, 2016 - bmj.com
Too much medicine in older people? Deprescribing through shared decision making Page 1 Too
much medicine in older people? Deprescribing through shared decision making Jansen and …

Pharmacokinetics and drug metabolism in the elderly

U Klotz - Drug metabolism reviews, 2009 - Taylor & Francis
Aging involves progressive impairments in the functional reserve of multiple organs, which
might also affect drug metabolism and pharmacokinetics. In addition, the elderly population …

Systematic review of anticholinergic risk scales in older adults

CE Durán, M Azermai, RH Vander Stichele - European journal of clinical …, 2013 - Springer
Background Anticholinergic drugs are often involved in explicit criteria for inappropriate
prescribing in older adults. Several scales were developed for screening of anticholinergic …

[HTML][HTML] Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis–an expert consensus addressing benefits as well as gastrointestinal …

C Scarpignato, A Lanas, C Blandizzi, WF Lems… - BMC medicine, 2015 - Springer
Background There are several guidelines addressing the issues around the use of NSAIDs.
However, none has specifically addressed the upper versus lower gastrointestinal (GI) risk …

[HTML][HTML] The advent of a new era in digital healthcare: a role for 3D printing technologies in drug manufacturing?

II Andreadis, CI Gioumouxouzis, GK Eleftheriadis… - Pharmaceutics, 2022 - mdpi.com
The technological revolution has physically affected all manufacturing domains, at the
gateway of the fourth industrial revolution. Three-dimensional (3D) printing has already …

High‐risk prescribing and incidence of frailty among older community‐dwelling men

D Gnjidic, SN Hilmer, FM Blyth… - Clinical …, 2012 - Wiley Online Library
Evidence about the association between treatment with high–risk medicines and frailty in
older individuals is limited. We investigated the relationship between high–risk prescribing …

Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study

I Carrière, A Fourrier-Reglat, JF Dartigues… - Archives of internal …, 2009 - jamanetwork.com
Background Despite the high intake of medications with anticholinergic properties by
community-dwelling elderly persons, the effects on cognitive decline and dementia have …