Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Circadian rhythms optimize physiology and health by temporally coordinating cellular
function, tissue function, and behavior. These endogenous rhythms dampen with age and …

The mammalian circadian clock consists of a transcription–translation feedback loop (TTFL)
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …

The mammalian circadian clock involves a transcriptional feed back loop in which CLOCK
and BMAL1 activate the Period and Cryptochrome genes, which then feedback and repress …

Stress constitutes a state of threatened homeostasis triggered by intrinsic or extrinsic
adverse forces (stressors) and is counteracted by an intricate repertoire of physiologic and …

Objective Few studies examined the association between time‐of‐day of nutrient intake and
the metabolic syndrome. Our goal was to compare a weight loss diet with high caloric intake …

Most organisms display endogenously produced∼ 24-hour fluctuations in physiology and
behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional …

Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …