The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …

The stereocontrolled construction of C− C bonds remains one of the foremost challenges in
organic synthesis. At the heart of any chemical synthesis of a natural product or designed …

Transition-metal-catalyzed nucleophilic addition of organometallic reagents to polar
unsaturated substrates is one of the most important and powerful bond-forming strategies …

In chemistry, a nucleophile is a molecule or ion with a lone pair of electrons. It donates both
bonding electrons to its reaction partner (the electrophile) when forming a chemical bond. 1 …

Carbon-carbon cross-coupling reactions are among the most useful and most widely studied
synthetic transformations. The three most important processes, the Heck reaction, the Suzuki …

Conspectus Oxidative cross-coupling reactions between two nucleophiles are a powerful
synthetic strategy to synthesize various kinds of functional molecules. Along with the …

The Pd-catalyzed reaction of an aryl halide with an alkene affords, in most cases, the
corresponding arylalkene. It is usually considered that this reaction, which is called the Heck …

The Heck reaction is one of the most studied coupling reactions and is recognized with the
Nobel Prize in Chemistry. Thousands of articles, hundreds of reviews and a number of …

Expedient Synthesis of N-Acyl Anthranilamides and β-Enamine Amides by the Rh(III)-Catalyzed
Amidation of Aryl and Vinyl C–H Bonds with Isocyanates | Journal of the American Chemical …

The first rhodium-catalyzed arylation of imines proceeding via C− H bond functionalization is
reported. Use of a non-coordinating halide abstractor is important to obtain reactivity. Aryl …