Alzheimer's disease (AD) is a mostly sporadic brain disorder characterized by cognitive
decline resulting from selective neurodegeneration in the hippocampus and cerebral cortex …

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …

Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …

Developing effective treatments for patients with Huntington's disease (HD)—a
neurodegenerative disorder characterized by severe cognitive, motor and psychiatric …

Huntington's disease (HD) is characterized by clinical motor impairment (eg, involuntary
movements, poor coordination, parkinsonism), cognitive deficits, and psychiatric symptoms …

Neurodegenerative disorders are characterized by neuronal loss, usually in late life. But
recently, abnormalities of proteins implicated in neurodegenerative disorders have been …

Huntington's disease is classically described as a neurodegenerative disorder of monogenic
aetiology. The disease is characterized by an abnormal polyglutamine expansion in the …

Tauopathies are a group of neurodegenerative diseases whose central feature is
dysfunction of the microtubule-associated protein tau (MAPT). Although the exact etiology of …

There is increasing evidence for the presence of pathological forms of tau in tissues of both
Huntington's disease (HD) patients and animal models of this condition. While cumulative …

Environmental exposures and/or alterations in the homeostasis of essential transition metals
(ETM), such as Fe, Cu, Zn or Mn, are known to contribute to neurodegenerative diseases …