DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
Targeting the DNA damage response in immuno-oncology: developments and opportunities
Immunotherapy has revolutionized cancer treatment and substantially improved patient
outcome with regard to multiple tumour types. However, most patients still do not benefit …
outcome with regard to multiple tumour types. However, most patients still do not benefit …
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
L Zhang, C Jiang, Y Zhong, K Sun, H Jing, J Song… - Nature Cell …, 2023 - nature.com
Evasion of antitumour immunity is a hallmark of cancer. STING, a putative innate immune
signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating …
signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating …
The complementarity of DDR, nucleic acids and anti-tumour immunity
Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …
STING enhances cell death through regulation of reactive oxygen species and DNA damage
Resistance to DNA-damaging agents is a significant cause of treatment failure and poor
outcomes in oncology. To identify unrecognized regulators of cell survival we performed a …
outcomes in oncology. To identify unrecognized regulators of cell survival we performed a …
Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling
Protection of stalled replication forks is crucial for cells to respond to replication stress and
maintain genome stability. Genome instability and replication stress have been linked to …
maintain genome stability. Genome instability and replication stress have been linked to …
Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation
Z Zhen, Y Chen, H Wang, H Tang, H Zhang… - Nature …, 2023 - nature.com
Abstract Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor,
detects DNA fragments to trigger an innate immune response. Recently, accumulating …
detects DNA fragments to trigger an innate immune response. Recently, accumulating …
cGAS‒STING signaling and function in metabolism and kidney diseases
The cyclic GMP‒AMP synthase (cGAS)‒stimulator of interferon genes (STING) signaling
pathway senses the presence of cytosolic DNA and, in turn, triggers downstream signaling …
pathway senses the presence of cytosolic DNA and, in turn, triggers downstream signaling …
[PDF][PDF] DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling
OPG Wheeler, L Unterholzner - Essays in Biochemistry, 2023 - portlandpress.com
The DNA sensor cGAS (cyclic GMP-AMP synthase) and its adaptor protein STING
(Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or …
(Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or …