Interleukins 4 and 13 in asthma: key pathophysiologic cytokines and druggable molecular targets
Interleukins (IL)-4 and-13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-
4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and …
4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and …
Molecular targets for biological therapies of severe asthma
C Pelaia, C Crimi, A Vatrella, C Tinello… - Frontiers in …, 2020 - frontiersin.org
Asthma is a heterogeneous respiratory disease characterized by usually reversible
bronchial obstruction, which is clinically expressed by different phenotypes driven by …
bronchial obstruction, which is clinically expressed by different phenotypes driven by …
Tezepelumab: a potential new biological therapy for severe refractory asthma
Thymic stromal lymphopoietin (TSLP) is an innate cytokine, belonging to the group of
alarmins, which plays a key pathogenic role in asthma by acting as an upstream activator of …
alarmins, which plays a key pathogenic role in asthma by acting as an upstream activator of …
Therapeutic effects of benralizumab assessed in patients with severe eosinophilic asthma: real-life evaluation correlated with allergic and non-allergic phenotype …
C Pelaia, C Crimi, A Benfante, MF Caiaffa… - Journal of Asthma …, 2021 - Taylor & Francis
Background Benralizumab can be utilized as add-on biological treatment of severe
eosinophilic asthma. However, so far only a few real-life studies have been published with …
eosinophilic asthma. However, so far only a few real-life studies have been published with …
Role of p38 mitogen-activated protein kinase in asthma and COPD: pathogenic aspects and potential targeted therapies
Among the various members of the mitogen-activated protein kinase (MAPK) family, p38
MAPK subgroup is the most involved in airway and lung inflammation underlying asthma …
MAPK subgroup is the most involved in airway and lung inflammation underlying asthma …
Real‐life evaluation of mepolizumab efficacy in patients with severe eosinophilic asthma, according to atopic trait and allergic phenotype
Abstract Background Anti‐interleukin‐5 (IL‐5) monoclonal antibodies can be used as add‐
on biological therapies in allergic and non‐allergic patients with severe eosinophilic asthma …
on biological therapies in allergic and non‐allergic patients with severe eosinophilic asthma …
Monoclonal antibodies targeting alarmins: a new perspective for biological therapies of severe asthma
C Pelaia, G Pelaia, F Longhini, C Crimi, C Calabrese… - Biomedicines, 2021 - mdpi.com
Alarmins are innate cytokines, including thymic stromal lymphopoietin (TSLP), interleukin-33
(IL-33), and interleukin-25 (IL-25), which are mainly produced by airway epithelium and …
(IL-33), and interleukin-25 (IL-25), which are mainly produced by airway epithelium and …
Novel biological therapies for severe asthma endotypes
Severe asthma comprises several heterogeneous phenotypes, underpinned by complex
pathomechanisms known as endotypes. The latter are driven by intercellular networks …
pathomechanisms known as endotypes. The latter are driven by intercellular networks …
Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy
X Han, S Hu, Q Yang, X Sang, D Tang, G Cao - Phytomedicine, 2022 - Elsevier
Background Asthma characterized by airway remodeling is a multiple pulmonary disease,
which is associated with various physiological processes including inflammation reaction …
which is associated with various physiological processes including inflammation reaction …
[HTML][HTML] N-3 PUFAs and their specialized pro-resolving lipid mediators on airway inflammatory response: beneficial effects in the prevention and treatment of …
J Zúñiga-Hernández, V Sambra, F Echeverría… - Food & Function, 2022 - pubs.rsc.org
Respiratory diseases include a wide range of pathologies with different clinical
manifestations, affecting the normal airways and lung function. An increase in the …
manifestations, affecting the normal airways and lung function. An increase in the …