Publisher Summary This chapter reviews the recent advancements in the study of the
transport and metabolism of thyroid hormone. It discusses the role of deiodination …

For a long time it has been known that both hypo-and hyperthyroidism are associated with
an increased risk of morbidity and mortality. In recent years, it has also become clear that …

Non-mendelian inheritance refers to the group of phenomena and observations related to
the inheritance of genetic information that cannot be merely explained by Mendel's laws of …

Genetic factors do not fully account for the relatively high heritability of neurodevelopmental
conditions, suggesting that non-genetic heritable factors contribute to their etiology. To …

Mammalian evolution entailed multiple innovations in gene regulation, including the
emergence of genomic imprinting, an epigenetic regulation leading to the preferential …

Thyroid hormones are essential for proper kidney growth and development. The kidney is
not only the organ of thyroid hormone metabolism but also the target organ of thyroid …

Thyroid hormones (THs) influence multiple processes in the developing and adult central
nervous system, and their local availability needs to be maintained at levels that are tailored …

Background: Evidence for transgenerational epigenetic inheritance in humans is still
controversial, given the requirement to demonstrate persistence of the phenotype across …

Intergenerational and transgenerational epigenetic effects resulting from conditions in
previous generations can contribute to environmental adaptation as well as disease …

Hypo-and hyperthyroid states, as well as functional abnormalities in the hypothalamic-
pituitary-thyroid axis have been associated with psychiatric conditions like anxiety and …