Over the last three decades, virus-like particles (VLPs) have evolved to become a widely
accepted technology, especially in the field of vaccinology. In fact, some VLP-based …

In December 1983, a seminal paper appeared on the overexpression of human IFN-β in
insect cells with a genetically engineered baculovirus. The finding that baculoviruses …

Virus‐like particles (VLPs) mimic the whole construct of virus particles devoid of viral
genome as used in subunit vaccine design. VLPs can elicit efficient protective immunity as …

Virus-like particle (VLP) technology is a promising approach for the construction of novel
vaccines, diagnostic tools, and gene therapy vectors. Initially, VLPs were primarily derived …

The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe
disease in humans and represents a serious public health threat in countries where Aedes …

Self-assembling protein nanoparticles are used as a novel vaccine design platform to
improve the stability and immunogenicity of safe subunit vaccines, while providing broader …

For 30 years it was thought the alphavirus 6K gene encoded a single 6 kDa protein.
However, through a bioinformatics search 10 years ago, it was discovered that there is a …

As fish farming continues to increase worldwide, the related research areas of fish disease
and immunology are also expanding, aided by the revolution in access to genomic …

In most breeding schemes, fish are cultured in enclosed spaces, which greatly increases the
risk of outbreaks where the onset of infectious diseases can cause massive mortality and …

CpG oligonucleotides and polyinosinic: polycytidylic acid (poly I: C) are toll-like receptor
(TLR) agonists that mimic the immunostimulatory properties of bacterial DNA and double …