Stress and defense responses in plant secondary metabolites production

T Isah - Biological research, 2019 - SciELO Chile
In the growth condition (s) of plants, numerous secondary metabolites (SMs) are produced
by them to serve variety of cellular functions essential for physiological processes, and …

Terpene synthases as metabolic gatekeepers in the evolution of plant terpenoid chemical diversity

PS Karunanithi, P Zerbe - Frontiers in plant science, 2019 - frontiersin.org
Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …

Oxetane ring formation in taxol biosynthesis is catalyzed by a bifunctional cytochrome P450 enzyme

Y Zhao, F Liang, Y Xie, YT Duan… - Journal of the …, 2023 - ACS Publications
Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted
extensive research into its biosynthesis. However, certain critical steps, such as the …

Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza

Y Ma, G Cui, T Chen, X Ma, R Wang, B Jin… - Nature …, 2021 - nature.com
Tanshinones are the bioactive nor-diterpenoid constituents of the Chinese medicinal herb
Danshen (Salvia miltiorrhiza). These groups of chemicals have the characteristic furan D …

Advances in biosynthesis, regulation, and metabolic engineering of plant specialized terpenoids

DA Nagegowda, P Gupta - Plant Science, 2020 - Elsevier
Plant specialized terpenoids are natural products that have no obvious role in growth and
development, but play many important functional roles to improve the plant's overall fitness …

[HTML][HTML] Cytochrome P450 enzymes: a driving force of plant diterpene diversity

U Bathe, A Tissier - Phytochemistry, 2019 - Elsevier
In plant terpene biosynthesis, oxidation of the hydrocarbon backbone produced by terpene
synthases is typically carried out by cytochrome P450 oxygenases (CYPs). The …

Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks

C Ignea, MH Raadam, A Koutsaviti, Y Zhao… - Nature …, 2022 - nature.com
Humankind relies on specialized metabolites for medicines, flavors, fragrances, and
numerous other valuable biomaterials. However, the chemical space occupied by …

Applications of synthetic biology in medical and pharmaceutical fields

X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells

X Zhu, X Liu, T Liu, Y Wang, N Ahmed, Z Li… - Plant Communications, 2021 - cell.com
Plant natural products (PNPs) are the main sources of drugs, food additives, and new
biofuels and have become a hotspot in synthetic biology. In the past two decades, the …

Carnosic acid and carnosol, two major antioxidants of rosemary, act through different mechanisms

M Loussouarn, A Krieger-Liszkay, L Svilar… - Plant …, 2017 - academic.oup.com
Carnosic acid, a phenolic diterpene specific to the Lamiaceae family, is highly abundant in
rosemary (Rosmarinus officinalis). Despite numerous industrial and medicinal …