Obesity and cancer mechanisms: tumor microenvironment and inflammation

NM Iyengar, A Gucalp, AJ Dannenberg… - Journal of clinical …, 2016 - ascopubs.org
Purpose There is growing evidence that inflammation is a central and reversible mechanism
through which obesity promotes cancer risk and progression. Methods We review recent …

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

A Takahashi-Kanemitsu, CT Knight… - Cellular & molecular …, 2020 - nature.com
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

LE Wroblewski, RM Peek Jr… - Clinical microbiology …, 2010 - Am Soc Microbiol
Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's
population. Infection with H. pylori causes chronic inflammation and significantly increases …

NF-κB and STAT3–key players in liver inflammation and cancer

G He, M Karin - Cell research, 2011 - nature.com
Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is one of the most
deadly human cancers. The pathogenesis of HCC is frequently linked with continuous …

Inflammation and cancer

LM Coussens, Z Werb - Nature, 2002 - nature.com
Recent data have expanded the concept that inflammation is a critical component of tumour
progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It …

Pathogenesis of Helicobacter pylori Infection

JG Kusters, AHM Van Vliet… - Clinical microbiology …, 2006 - Am Soc Microbiol
Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the
most successful human pathogens, as over half of the world's population is colonized with …

Helicobacter pylori and gastrointestinal tract adenocarcinomas

RM Peek Jr, MJ Blaser - Nature Reviews Cancer, 2002 - nature.com
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in
the stomach, only a small fraction of colonized individuals develop this common malignancy …

Tumor stroma and regulation of cancer development

TD Tlsty, LM Coussens - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
In the past 25 years, a majority of cancer studies have focused on examining functional
consequences of activating and/or inactivating mutations in critical genes implicated in cell …

Probiotics—from Metchnikoff to bioactives

T Vasiljevic, NP Shah - International dairy journal, 2008 - Elsevier
The benefits of probiotics have been recognized and explored for over a century. The
pioneering work of Tissier and Moro was elaborated in the Metchnikoff's theory of longevity …

Microbial agents associated with waterborne diseases

H Leclerc, L Schwartzbrod… - Critical reviews in …, 2002 - Taylor & Francis
Four epidemiological categories were initially devised for classifying water-related infectious
“diseases” with regard to the engineering technologies required to prevent or control them …