Proteins regulating the mammalian target of rapamycin (mTOR), as well as some of the
targets of the mTOR kinase, are overexpressed or mutated in cancer. Rapamycin, the …

Rapamycin and its derivatives are promising therapeutic agents with both
immunosuppressant and anti-tumor properties. These rapamycin actions are mediated …

The circadian timing system synchronizes cellular function by coordinating rhythmic
transcription via a transcription-translational feedback loop. How the circadian system …

The 40 S ribosomal S6 kinase 1 (S6K1) acts downstream of mTOR (mammalian target of
rapamycin) and is sensitive to inhibition by rapamycin. The chromosomal region 17q23 …

To identify new immortalizing genes with potential roles in tumorigenesis, we performed a
genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts …

The mammalian target of rapamycin (mTOR) pathway plays a central role in regulating
protein synthesis, ribosomal protein translation, and cap-dependent translation …

Current understanding of the mechanisms by which cell growth is regulated lags
significantly behind our knowledge of the complex processes controlling cell cycle …

Glioblastomas frequently carry mutations in the PTEN tumor suppressor gene on 10q23. 3.
The tumor suppressor properties of Pten are closely related to its inhibitory effect on the …

Background: Studies by comparative genomic hybridization (CGH) have shown that
chromosomal region 17q23 is amplified in up to 20% of primary breast cancers. We used …

Breast cancer cell lines provide a useful starting point for the discovery and functional
analysis of genes involved in breast cancer. Here, we studied 38 established breast cancer …