Various human diseases can disrupt the balance between muscle contraction and
relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by …

The incidence of chronic wounds is increased among older adults, and the impact of chronic
wounds on quality of life is particularly profound in this population. It is well established that …

The increasing global prevalence of chronic wounds underscores the growing importance of
developing effective animal models for their study. This review offers a critical evaluation of …

Background: Atherosclerotic peripheral artery disease affects 8% to 12% of Americans> 65
years of age and is associated with a major decline in functional status, increased …

Despite the regenerative capacity of skeletal muscle, permanent functional and/or cosmetic
deficits (eg, volumetric muscle loss (VML) resulting from traumatic injury, disease and …

Post-stroke antiplatelet therapy has been proved to reduce the risk of recurrent stroke;
however, it may also increase the incidence of intracranial hemorrhage that could offset any …

Background K-134 is a more potent antiplatelet drug with a selective inhibitory effect on
phosphodiesterase 3 (PDE3) compared with its analogue, cilostazol. Objectives This study …

Background The efficacy of P2Y12 inhibition for the prevention of cardiovascular events in
patients with peripheral arterial disease (PAD) has been established. However, the …

K-134, a phosphodiesterase 3 (PDE3) inhibitor with anti-thrombotic and anti-hyperplastic
activity, is being developed for the treatment of intermittent claudication. We assessed the …

Background T cell-induced inflammatory response and related cytokine secretion at the
injury site may participate in the pathogenesis of cerebral infarction. Recent studies …