Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms …

M Valipour - European journal of medicinal chemistry, 2022 - Elsevier
Shikonin and its enantiomeric analogue, alkaninn, are prevailing natural lead compounds in
the drug discovery and development of anticancer agents. Despite having numerous …

2-Aminobenzothiazoles in anticancer drug design and discovery

G Huang, T Cierpicki, J Grembecka - Bioorganic chemistry, 2023 - Elsevier
Cancer is one of the major causes of mortality and morbidity worldwide. Substantial
research efforts have been made to develop new chemical entities with improved anticancer …

[HTML][HTML] The pursuit of accurate predictive models of the bioactivity of small molecules

K Martinez-Mayorga, JG Rosas-Jiménez… - Chemical …, 2024 - pubs.rsc.org
Property prediction is a key interest in chemistry. For several decades there has been a
continued and incremental development of mathematical models to predict properties. As …

Discovery of benzochalcone derivative as a potential antigastric cancer agent targeting signal transducer and activator of transcription 3 (STAT3)

J Dong, J Yang, W Yu, H Li, M Cai, JL Xu… - Journal of Enzyme …, 2022 - Taylor & Francis
Gastric cancer remains a significant health burden worldwide. In continuation of our
previous study and development of effective small molecules against gastric cancer, a series …

Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer

A Podolski-Renić, AČ Gašparović, A Valente… - European Journal of …, 2024 - Elsevier
Overcoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In
this respect, Schiff base-related compounds (bearing a R 1 R 2 Cdouble bondNR 3 bond) …

[HTML][HTML] The fundamental role of oxime and oxime ether moieties in improving the physicochemical and anticancer properties of structurally diverse scaffolds

J Fotie, CM Matherne, JB Mather… - International Journal of …, 2023 - mdpi.com
The present review explores the critical role of oxime and oxime ether moieties in enhancing
the physicochemical and anticancer properties of structurally diverse molecular frameworks …

[HTML][HTML] Unlocking the potential of 1, 4-naphthoquinones: A comprehensive review of their anticancer properties

E Angulo-Elizari, A Henriquez-Figuereo… - European Journal of …, 2024 - Elsevier
Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

Thiourea Derivatives based on the dapsone‐naphthoquinone hybrid as anticancer and antimicrobial agents: in vitro screening and molecular docking studies

A Alimohammadi, H Mostafavi, M Mahdavi - ChemistrySelect, 2020 - Wiley Online Library
According to the structure‐activity relationships (SAR), we synthesized a series of novel
thiourea derivatives based on the dapsone‐naphthoquinone hybrid by the nucleophilic …

Discovery of fast-acting dual-stage antimalarial agents by profiling pyridylvinylquinoline chemical space via copper catalyzed azide-alkyne cycloadditions

G Huang, CM Solano, J Melendez, S Yu-Alfonzo… - European journal of …, 2021 - Elsevier
To identity fast-acting, multistage antimalarial agents, a series of pyridylvinylquinoline-
triazole analogues have been synthesized via CuAAC. Most of the compounds display …

Copper-catalyzed selective oxidation of hydrazones through C (sp 3)–H functionalization

J Shen, X Jiang, H Wu, J Xu, Q Zhu… - Organic & Biomolecular …, 2021 - pubs.rsc.org
A simple and mild protocol for copper-catalyzed oxidation of hydrazones at the α-position
has been reported. Various substrates are compatible, providing the corresponding products …