Metabolism and metabolites of polychlorinated biphenyls

FA Grimm, D Hu, I Kania-Korwel… - Critical reviews in …, 2015 - Taylor & Francis
The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on
toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable …

Chiral toxicology: it's the same thing… only different

SW Smith - Toxicological sciences, 2009 - academic.oup.com
Chiral substances possess a unique architecture such that, despite sharing identical
molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be …

Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment

PE Goines, P Ashwood - Neurotoxicology and teratology, 2013 - Elsevier
Autism spectrum disorders (ASD) are neurodevelopmental diseases that affect an alarming
number of individuals. The etiological basis of ASD is unclear, and evidence suggests it …

Evidence implicating non-dioxin-like congeners as the key mediators of polychlorinated biphenyl (PCB) developmental neurotoxicity

C Klocke, PJ Lein - International journal of molecular sciences, 2020 - mdpi.com
Despite being banned from production for decades, polychlorinated biphenyls (PCBs)
continue to pose a significant risk to human health. This is due to not only the continued …

[HTML][HTML] Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods

A Bal-Price, F Pistollato, M Sachana, SK Bopp… - Toxicology and applied …, 2018 - Elsevier
Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …

Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

IN Pessah, G Cherednichenko, PJ Lein - Pharmacology & therapeutics, 2010 - Elsevier
Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public
health concern since results from epidemiological studies indicate that PCB burden is …

Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants

F Fonnum, E Mariussen - Journal of neurochemistry, 2009 - Wiley Online Library
Many toxic substances have been distributed to the environment, some of which have
properties that promote accumulation and biomagnification in living organisms …

The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences

C Klocke, S Sethi, PJ Lein - Environmental Science and Pollution …, 2020 - Springer
Although banned from production for decades, PCBs remain a significant risk to human
health. A primary target of concern is the developing brain. Epidemiological studies link PCB …

Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor

S Sethi, RK Morgan, W Feng, Y Lin, X Li… - … science & technology, 2019 - ACS Publications
Polychlorinated biphenyls (PCBs) pose significant risk to the developing human brain;
however, mechanisms of PCB developmental neurotoxicity (DNT) remain controversial. Two …

Chiral polychlorinated biphenyl transport, metabolism, and distribution: a review

HJ Lehmler, SJ Harrad, H Hühnerfuss… - … science & technology, 2010 - ACS Publications
Chirality can be exploited to gain insight into enantioselective fate processes that may
otherwise remain undetected because only biological, but not physical and chemical …