Metabolism and metabolites of polychlorinated biphenyls
FA Grimm, D Hu, I Kania-Korwel… - Critical reviews in …, 2015 - Taylor & Francis
The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on
toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable …
toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable …
Chiral toxicology: it's the same thing… only different
SW Smith - Toxicological sciences, 2009 - academic.oup.com
Chiral substances possess a unique architecture such that, despite sharing identical
molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be …
molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be …
Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment
PE Goines, P Ashwood - Neurotoxicology and teratology, 2013 - Elsevier
Autism spectrum disorders (ASD) are neurodevelopmental diseases that affect an alarming
number of individuals. The etiological basis of ASD is unclear, and evidence suggests it …
number of individuals. The etiological basis of ASD is unclear, and evidence suggests it …
Evidence implicating non-dioxin-like congeners as the key mediators of polychlorinated biphenyl (PCB) developmental neurotoxicity
Despite being banned from production for decades, polychlorinated biphenyls (PCBs)
continue to pose a significant risk to human health. This is due to not only the continued …
continue to pose a significant risk to human health. This is due to not only the continued …
[HTML][HTML] Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods
A Bal-Price, F Pistollato, M Sachana, SK Bopp… - Toxicology and applied …, 2018 - Elsevier
Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …
Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity
Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public
health concern since results from epidemiological studies indicate that PCB burden is …
health concern since results from epidemiological studies indicate that PCB burden is …
Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants
F Fonnum, E Mariussen - Journal of neurochemistry, 2009 - Wiley Online Library
Many toxic substances have been distributed to the environment, some of which have
properties that promote accumulation and biomagnification in living organisms …
properties that promote accumulation and biomagnification in living organisms …
The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences
Although banned from production for decades, PCBs remain a significant risk to human
health. A primary target of concern is the developing brain. Epidemiological studies link PCB …
health. A primary target of concern is the developing brain. Epidemiological studies link PCB …
Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor
Polychlorinated biphenyls (PCBs) pose significant risk to the developing human brain;
however, mechanisms of PCB developmental neurotoxicity (DNT) remain controversial. Two …
however, mechanisms of PCB developmental neurotoxicity (DNT) remain controversial. Two …
Chiral polychlorinated biphenyl transport, metabolism, and distribution: a review
HJ Lehmler, SJ Harrad, H Hühnerfuss… - … science & technology, 2010 - ACS Publications
Chirality can be exploited to gain insight into enantioselective fate processes that may
otherwise remain undetected because only biological, but not physical and chemical …
otherwise remain undetected because only biological, but not physical and chemical …