Chronic liver disease (CLD) and its associated complications (cirrhosis and liver cancer)
cause significant mortality, morbidity, and economic burden. Published data from the World …

As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence
of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of …

Autoimmune hepatitis (AIH) is a severe liver disease that affects children and adults
worldwide. The diagnosis of AIH relies on increased serum transaminase and …

Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes progressive liver damage,
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …

Background: End-stage liver disease is a common cause of morbidity and mortality
worldwide, yet little is known about its symptomatology and impact on health-related quality …

Liver regeneration has been studied for many decades and the mechanisms underlying
regeneration of the normal liver following resection or moderate damage are well described …

Background & Aims Non-alcoholic steatohepatitis (NASH) is associated with increased
mortality and a high clinical burden. NASH adversely impacts patients' health-related quality …

Cirrhosis is a burden on the individual and on public health. The World Health
Organization's metric of public health burden is the disability-adjusted life-year (DALY), the …

Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We
conducted a first-in-human, phase 1 dose-escalation trial of autologous macrophage …

Abstract Non-Alcoholic Fatty Liver Disease (NAFLD), a progressive liver disease that is
closely associated with obesity, type 2 diabetes, hypertension and dyslipidaemia, represents …