Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration

KS Lee, S Lin, DA Copland, AD Dick, J Liu - Journal of Neuroinflammation, 2021 - Springer
Age-related macular degeneration (AMD), a degenerative disease in the central macula
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …

Retinitis pigmentosa: current clinical management and emerging therapies

XTA Nguyen, L Moekotte, AS Plomp… - International journal of …, 2023 - mdpi.com
Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies characterized
by the degeneration of rod photoreceptors, followed by the degeneration of cone …

Prevalence of visual acuity loss or blindness in the US: a Bayesian meta-analysis

AD Flaxman, JS Wittenborn, T Robalik… - JAMA …, 2021 - jamanetwork.com
Importance Globally, more than 250 million people live with visual acuity loss or blindness,
and people in the US fear losing vision more than memory, hearing, or speech. But it …

Evaluating whether sight is the most valued sense

J Enoch, L McDonald, L Jones, PR Jones… - JAMA …, 2019 - jamanetwork.com
Importance Sight is often considered to be the sense most valued by the general public, but
there are limited empirical data to support this. This study provides empirical evidence for …

Advanced visualization engineering for vision disorders: a clinically focused guide to current technology and future applications

N Zaman, J Ong, E Waisberg, M Masalkhi… - Annals of Biomedical …, 2024 - Springer
Head-mounted visualization technology, often in the form of virtual, augmented, and mixed
reality (VAMR), has revolutionized how visual disorders may be approached clinically. In this …

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results

S Crespo-Garcia, F Fournier, R Diaz-Marin, S Klier… - Nature Medicine, 2024 - nature.com
Compromised vascular endothelial barrier function is a salient feature of diabetic
complications such as sight-threatening diabetic macular edema (DME). Current standards …

Visual impairment, severe visual impairment, and blindness in children in Britain (BCVIS2): a national observational study

LJ Teoh, AL Solebo, JS Rahi, J Abbott… - The Lancet Child & …, 2021 - thelancet.com
Summary Background The WHO VISION 2020 global initiative against blindness, launched
in 2000, prioritised childhood visual disability by aiming to end avoidable childhood …

The primate model for understanding and restoring vision

S Picaud, D Dalkara, K Marazova… - Proceedings of the …, 2019 - National Acad Sciences
Retinal degenerative diseases caused by photoreceptor cell death are major causes of
irreversible vision loss. As only primates have a macula, the nonhuman primate (NHP) …

An eye on age-related macular degeneration: the role of microRNAs in disease pathology

P Berber, F Grassmann, C Kiel, BHF Weber - Molecular diagnosis & …, 2017 - Springer
Age-related macular degeneration (AMD) is the primary cause of blindness in developed
countries, and is the third leading cause worldwide. Emerging evidence suggests that …

The roles of sex and gender in women's eye health disparities in the United States

IO Aninye, K Digre, ME Hartnett, K Baldonado… - Biology of sex …, 2021 - Springer
Abstract Background In the United States, women are at a higher risk of developing vision
impairment or a serious eye disease (such as age-related macular degeneration, thyroid …