Interplay between physiological systems in the body plays a prominent role in health and
disease. At the cellular level, such interplay is orchestrated through the binding of specific …

Neuropeptide Y targets the Y1 receptor (Y1) in the spinal dorsal horn (DH) to produce
endogenous and exogenous analgesia. DH interneurons that express Y1 (Y1-INs; encoded …

Itch (pruritus) is a common chronic condition with a lifetime prevalence of over 20%. The
mechanisms underlying itch are poorly understood, and its therapy is difficult. There is …

Sensitive skin syndrome has a neuropathic origin, which is why it is frequently associated
with irritable bowel syndrome. We have looked for a possible association with chronic …

Pruritus is a common irritating sensation that provokes the desire to scratch. Environmental
and genetic factors contribute to the onset of pruritus. Moreover, itch can become a major …

Background: Notalgia paresthetica (NP) is a form of neuropathic itch characterized by
recurrent itch in the mid back. Much about NP remains unclear, especially the patient …

瘙痒是一种可引起抓挠行为的不愉快的躯体感觉. 许多皮肤疾病及一些系统性疾病等都存在慢性
瘙痒的症状, 顽固而剧烈的瘙痒严重影响患者的身心健康和生活质量. 稳定可靠且能模拟临床的 …

Conclusion NP is a complex disease process that stems from altered function of the
somatosensory system at multiple levels (Fig 1). Increased understanding of itch …

Pain and itch are both important manifestations of various disorders, such as herpes zoster,
atopic dermatitis, and psoriasis. Growing evidence suggests that both sensations have …

Chronic pruritus is a common and distressing condition in the elderly population, frequently
associated with various underlying systemic diseases and age-related skin changes …