The use of induced Pluripotent Stem Cells (iPSC) as a source of autologous tissues shows
great promise in regenerative medicine. Nevertheless, several major challenges remain to …

Though AsCas12a fills a crucial gap in the current genome editing toolbox, it exhibits
relatively poor editing efficiency, restricting its overall utility. Here we isolate an engineered …

Generation of human-induced pluripotent stem cells (iPSCs) from somatic cells has opened
the possibility to design novel therapeutic approaches. In 2014, the first-in-human clinical …

Human pluripotent stem cells (hPSCs) are capable of extensive self-renewal yet remain
highly sensitive to environmental perturbations in vitro, posing challenges to their …

Familial dysautonomia (FD), a rare neurodevelopmental and neurodegenerative disorder
affects the sympathetic and sensory nervous system. Although almost all patients harbor a …

Efficient translation of human induced pluripotent stem cells (hiPSCs) requires scalable cell
manufacturing strategies for optimal self-renewal and functional differentiation. Traditional …

O-GlcNAcylation is a post-translational modification (PTM) that regulates a wide range of
cellular functions and has been associated with multiple metabolic diseases in various …

The three peripheral sensory neuron (SN) subtypes, nociceptors, mechanoreceptors, and
proprioceptors, localize to dorsal root ganglia and convey sensations such as pain …

Balanced signal transduction is crucial in tissue patterning, particularly in the vasculature.
Heterotopic ossification (HO) is tightly linked to vascularization with increased vessel …

Human pluripotent stem cells can be differentiated into midbrain dopaminergic (mDA)
neurons by directing cells through a floor plate progenitor stage. The developmental identity …