Mechanistic pathways of sex differences in cardiovascular disease

V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2017 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

Estrogen and the cardiovascular system

AA Knowlton, AR Lee - Pharmacology & therapeutics, 2012 - Elsevier
Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated.
Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which …

Sex and gender differences in myocarditis and dilated cardiomyopathy

DL Fairweather, LT Cooper Jr, LA Blauwet - Current problems in cardiology, 2013 - Elsevier
Heart failure due to nonischemic dilated cardiomyopathy (DCM) contributes significantly to
the global burden of cardiovascular disease. Myocarditis is, in turn, a major cause of acute …

Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women: proceedings of the workshop held in Brussels on …

AHEM Maas, YT van der Schouw… - European heart …, 2011 - academic.oup.com
A recent report of the EuroHeart project has shown that women are still underrepresented in
many cardiovascular clinical trials, while important gender differences are present within …

Sex in basic research: concepts in the cardiovascular field

R Ventura-Clapier, E Dworatzek… - Cardiovascular …, 2017 - academic.oup.com
Women and men, female and male animals and cells are biologically different, and
acknowledgement of this fact is critical to advancing medicine. However, incorporating …

Gender and survival in patients with heart failure: interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta‐analysis

M Martínez‐Sellés, RN Doughty… - European journal of …, 2012 - Wiley Online Library
Aim The aim of this study was to investigate the relationship between gender and survival of
patients with heart failure, using data from both randomized trials and observational studies …

Sex‐and age‐based differences in the natural history and outcome of dilated cardiomyopathy

BP Halliday, A Gulati, A Ali, S Newsome… - European journal of …, 2018 - Wiley Online Library
Aim To evaluate the relationship between sex, age and outcome in dilated cardiomyopathy
(DCM). Methods and results We used proportional hazard modelling to examine the …

Periodontal inflammation: Integrating genes and dysbiosis

S Zhang, N Yu, RM Arce - Periodontology 2000, 2020 - Wiley Online Library
Biofilm bacteria co‐evolve and reach a symbiosis with the host on the gingival surface. The
disruption of the homeostatic relationship between plaque bacteria and the host can initiate …

Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the …

C Perrino, AL Barabási, G Condorelli… - Cardiovascular …, 2017 - academic.oup.com
Despite advances in myocardial reperfusion therapies, acute myocardial
ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number …

Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena

S Costantino, P Libby, R Kishore, JC Tardif… - European heart …, 2018 - academic.oup.com
Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide and also
inflict major burdens on morbidity, quality of life, and societal costs. Considering that CVD …