Biology and therapeutic potential of mesenchymal stem cell‐derived exosomes

Z Xunian, R Kalluri - Cancer Science, 2020 - Wiley Online Library
Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to
differentiate into several cell types. MSC‐based therapy has emerged as a promising …

Unlocking the power of exosomes for crossing biological barriers in drug delivery

RO Elliott, M He - Pharmaceutics, 2021 - mdpi.com
Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup
of nanovesicles called exosomes has been driving the research field to a new regime for …

Insight into extracellular vesicle-cell communication: from cell recognition to intracellular fate

L Ginini, S Billan, E Fridman, Z Gil - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …

Exosomes and other extracellular vesicles in host–pathogen interactions

JS Schorey, Y Cheng, PP Singh, VL Smith - EMBO reports, 2015 - embopress.org
An effective immune response requires the engagement of host receptors by pathogen‐
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

M Record, K Carayon, M Poirot… - Biochimica et Biophysica …, 2014 - Elsevier
Exosomes are nanovesicles that have emerged as a new intercellular communication
system between an intracellular compartment of a donor cell towards the periphery or an …

Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

AV Vlassov, S Magdaleno, R Setterquist… - Biochimica et Biophysica …, 2012 - Elsevier
BACKGROUND: Cells continuously secrete a large number of microvesicles,
macromolecular complexes, and small molecules into the extracellular space. Of the …

Extracellular vesicles: lipids as key components of their biogenesis and functions

M Record, S Silvente-Poirot, M Poirot… - Journal of lipid …, 2018 - ASBMB
Intercellular communication has been known for decades to involve either direct contact
between cells or to operate via circulating molecules, such as cytokines, growth factors, or …

hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation

G Sun, G Li, D Li, W Huang, R Zhang, H Zhang… - Materials Science and …, 2018 - Elsevier
The exploration of effective spinal cord injury (SCI) healing still remain a great challenge
due to the high morbidity, complex pathology and unclear targets. Human umbilical cord …

Membrane vesicles as conveyors of immune responses

C Théry, M Ostrowski, E Segura - Nature reviews immunology, 2009 - nature.com
In multicellular organisms, communication between cells mainly involves the secretion of
proteins that then bind to receptors on neighbouring cells. But another mode of intercellular …

Dexosomes as a cell-free vaccine for cancer immunotherapy

S Nikfarjam, J Rezaie, F Kashanchi, R Jafari - Journal of Experimental & …, 2020 - Springer
Dendritic cells (DCs) secrete vast quantities of exosomes termed as dexosomes.
Dexosomes are symmetric nanoscale heat-stable vesicles that consist of a lipid bilayer …