Et tu, Neisseria? Conflicts of Interest Between Neisseria Species

R Baerentsen, CM Tang, RM Exley - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Neisseria meningitidis and Neisseria gonorrhoeae are two obligate human pathogens that
have evolved to be uniquely adapted to their host. The meningococcus is frequently carried …

[HTML][HTML] Practical considerations for a TB controlled human infection model (TB-CHIM); the case for TB-CHIM in Africa, a systematic review of the literature and report …

SB Gordon, S Sichone, AE Chirwa… - Wellcome Open …, 2023 - ncbi.nlm.nih.gov
Background: Tuberculosis (TB) remains a major challenge in many domains including
diagnosis, pathogenesis, prevention, treatment, drug resistance and long-term protection of …

Effect of colonisation with Neisseria lactamica on cross-reactive anti-meningococcal B-cell responses: a randomised, controlled, human infection trial

AP Dale, AA Theodosiou, DF Gbesemete… - The Lancet …, 2022 - thelancet.com
Background Pharyngeal colonisation by the commensal bacterium Neisseria lactamica
inhibits colonisation by Neisseria meningitidis and has an inverse epidemiological …

Optimising vaccine immunogenicity in ageing populations: key strategies

G Jiang, Y Zou, D Zhao, J Yu - The Lancet Infectious Diseases, 2024 - thelancet.com
Vaccination has been shown to be the most effective means of preventing infectious
diseases, although older people commonly have a suboptimal immune response to …

Controlled human infection with Neisseria lactamica in late pregnancy to measure horizontal transmission and microbiome changes in mother–neonate pairs: a single …

AA Theodosiou, JR Laver, AP Dale, DW Cleary… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Infant upper respiratory microbiota are derived partly from the maternal
respiratory tract, and certain microbiota are associated with altered risk of infections and …

Vertebrate and Invertebrate Animal and New In Vitro Models for Studying Neisseria Biology

MM Girgis, M Christodoulides - Pathogens, 2023 - mdpi.com
The history of Neisseria research has involved the use of a wide variety of vertebrate and
invertebrate animal models, from insects to humans. In this review, we itemise these models …

Neisseria lactamica Controlled Human Infection Model

AP Dale, DF Gbesemete, RC Read… - … Vaccines: Methods and …, 2021 - Springer
Neisseria lactamica is a nonpathogenic commensal of the human upper respiratory tract that
has been associated with protection against N. meningitidis colonization and disease. We …

[PDF][PDF] Controlled human infection in late pregnancy: a single-arm interventional pilot trial investigating 3 mother-to-infant ransmission of Neisseria lactamica

AA Theodosiou, D Bogaert, DW Clearly… - The Lancet …, 2024 - eprints.soton.ac.uk
The infant respiratory microbiome is derived largely from its mother and is associated with 3
downstream health and disease. Manipulating maternal respiratory flora peripartum to 4 …

Genetic Manipulation of Neisseria gonorrhoeae and Commensal Neisseria Species

JP Dillard, JM Chan - Current Protocols, 2024 - Wiley Online Library
The sexually transmitted pathogen, Neisseria gonorrhoeae, undergoes natural
transformation at high frequency. This property has led to the rapid dissemination of …

[PDF][PDF] Controlled human infection with Neisseria lactamica

DF Gbesemete - 2024 - eprints.soton.ac.uk
Meningococcal disease is a globally important cause of mortality and morbidity, particularly
in the meningitis belt of Sub-Saharan Africa. The causative agent, Neisseria meningitidis …