Beyond polydimethylsiloxane: alternative materials for fabrication of organ-on-a-chip devices and microphysiological systems
Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …
Microfluidic organ-on-a-chip models of human liver tissue
The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
Volumetric bioprinting of organoids and optically tuned hydrogels to build liver‐like metabolic biofactories
PN Bernal, M Bouwmeester, J Madrid‐Wolff… - Advanced …, 2022 - Wiley Online Library
Organ‐and tissue‐level biological functions are intimately linked to microscale cell–cell
interactions and to the overarching tissue architecture. Together, biofabrication and …
interactions and to the overarching tissue architecture. Together, biofabrication and …
Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening
Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB)
remains a formidable challenge for central nervous system drug development. High‐fidelity …
remains a formidable challenge for central nervous system drug development. High‐fidelity …
A liver-on-a-chip platform with bioprinted hepatic spheroids
The inadequacy of animal models in correctly predicting drug and biothreat agent toxicity in
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …
Optimization of collagen type I-hyaluronan hybrid bioink for 3D bioprinted liver microenvironments
A Mazzocchi, M Devarasetty, R Huntwork, S Soker… - …, 2018 - iopscience.iop.org
Current 3D printing of tissue is restricted by the use of biomaterials that do not recapitulate
the native properties of the extracellular matrix (ECM). These restrictions have thus far …
the native properties of the extracellular matrix (ECM). These restrictions have thus far …
Recent advances in body-on-a-chip systems
Microphysiological systems (MPS, also known as “organ-on-a-chip”,“body-on-a-chip”, or
“human-on-a-chip”) have emerged over the last 15 years as attractive systems to probe …
“human-on-a-chip”) have emerged over the last 15 years as attractive systems to probe …
Recurrent urinary tract infection: a mystery in search of better model systems
BO Murray, C Flores, C Williams… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
Advances in passively driven microfluidics and lab-on-chip devices: A comprehensive literature review and patent analysis
The development of passively driven microfluidic labs on chips has been increasing over the
years. In the passive approach, the microfluids are usually driven and operated without any …
years. In the passive approach, the microfluids are usually driven and operated without any …
[HTML][HTML] Microfluidic platforms for cell cultures and investigations
This review covers several aspects of microfluidic devices used for culturing and monitoring
of both adherent and non-adherent cells, including a multitude of applications. A comparison …
of both adherent and non-adherent cells, including a multitude of applications. A comparison …