Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - Elsevier
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

[HTML][HTML] Advances in the early diagnosis of hepatocellular carcinoma

W Wang, C Wei - Genes & diseases, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers globally. In contrast to
the declining death rates observed for all other common cancers such as breast, lung, and …

Guide to metabolomics analysis: a bioinformatics workflow

Y Chen, EM Li, LY Xu - Metabolites, 2022 - mdpi.com
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The
key purpose of metabolomics is to identify the metabolites corresponding to each biological …

[PDF][PDF] A Large‐scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma

P Luo, P Yin, R Hua, Y Tan, Z Li, G Qiu, Z Yin… - …, 2018 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of
effective biomarkers for the early detection of HCC results in unsatisfactory curative …

Cancer metabolomic markers in urine: evidence, techniques and recommendations

SS Dinges, A Hohm, LA Vandergrift, J Nowak… - Nature reviews …, 2019 - nature.com
Urinary tests have been used as noninvasive, cost-effective tools for screening, diagnosis
and monitoring of diseases since ancient times. As we progress through the 21st century …

Magnetic resonance spectroscopy: principles and techniques: lessons for clinicians

JM Tognarelli, M Dawood, MIF Shariff… - Journal of clinical and …, 2015 - Elsevier
Magnetic resonance spectroscopy (MRS) provides a non-invasive 'window'on biochemical
processes within the body. Its use is no longer restricted to the field of research, with …

Metabolomics technology and bioinformatics for precision medicine

RK Azad, V Shulaev - Briefings in bioinformatics, 2019 - academic.oup.com
Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small
group or even individual patients based on their genetics, environment and lifestyle …

Recommendations and standardization of biomarker quantification using NMR-based metabolomics with particular focus on urinary analysis

AH Emwas, R Roy, RT McKay, D Ryan… - Journal of proteome …, 2016 - ACS Publications
NMR-based metabolomics has shown considerable promise in disease diagnosis and
biomarker discovery because it allows one to nondestructively identify and quantify large …

Clinical characteristics and outcomes of patients with cirrhosis and hepatocellular carcinoma in The Gambia, west Africa: a prospective cohort study

G Ndow, E Vo-Quang, Y Shimakawa… - The Lancet Global …, 2023 - thelancet.com
Background Chronic liver disease is a major cause of premature death in sub-Saharan
Africa. Efficacy of antiviral therapy among patients with hepatitis B virus (HBV)-related …

The two sides of creatine in cancer

L Zhang, P Bu - Trends in cell biology, 2022 - cell.com
Creatine is a nitrogen-containing organic acid naturally existing in mammals. It can be
converted into phosphocreatine to provide energy for muscle and nerve tissues. Creatine …