Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Plants are exposed to an ever-changing environment to which they have to adjust
accordingly. Their response is tightly regulated by complex signaling pathways that all start …

Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation
channel that serves as the primary heat and capsaicin sensor in humans. Using cryo-EM, we …

The ability to sense external temperature is assumed by somatosensory neurons, in which
temperature information is converted to neural activity by afferent input to the central nervous …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Numerous physiological functions rely on distinguishing temperature through temperature-
sensitive transient receptor potential channels (thermo-TRPs). Although the function of …

Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Temperature is a key environmental cue that influences the distribution and behavior of
plants globally. Understanding how plants sense temperature and integrate this information …

Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that
are involved in a variety of physiological processes. Within the TRPM family, member 8 …