Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape

NI Mazur, J Terstappen, R Baral, A Bardají… - The Lancet Infectious …, 2023 - thelancet.com
Respiratory syncytial virus is the second most common cause of infant mortality and a major
cause of morbidity and mortality in older adults (aged> 60 years). Efforts to develop a …

[HTML][HTML] The disease burden of influenza beyond respiratory illness

AE Macias, JE McElhaney, SS Chaves, J Nealon… - Vaccine, 2021 - Elsevier
Although influenza is primarily considered a respiratory infection and causes significant
respiratory mortality, evidence suggests that influenza has an additional burden due to …

Off-season RSV epidemics in Australia after easing of COVID-19 restrictions

JS Eden, C Sikazwe, R Xie, YM Deng… - Nature …, 2022 - nature.com
Human respiratory syncytial virus (RSV) is an important cause of acute respiratory infection
with the most severe disease in the young and elderly. Non-pharmaceutical interventions …

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

SNY Yang, SC Atkinson, C Wang, A Lee… - Antiviral research, 2020 - Elsevier
Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and
dengue virus (DENV) represent a major burden for human health worldwide. Although RNA …

Global burden of upper respiratory infections in 204 countries and territories, from 1990 to 2019

X Jin, J Ren, R Li, Y Gao, H Zhang, J Li, J Zhang… - …, 2021 - thelancet.com
Abstract Background Upper respiratory infections (URIs) are among the most common
diseases. However, the related burden has not been comprehensively evaluated. Thus, we …

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

LA Vella, JR Giles, AE Baxter, DA Oldridge… - Science …, 2021 - science.org
Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children …

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

AD Iuliano, KM Roguski, HH Chang, DJ Muscatello… - The Lancet, 2018 - thelancet.com
Background Estimates of influenza-associated mortality are important for national and
international decision making on public health priorities. Previous estimates of 250 000–500 …

Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

X Wang, Y Li, KL O'brien, SA Madhi… - The Lancet Global …, 2020 - thelancet.com
Background Seasonal influenza virus is a common cause of acute lower respiratory infection
(ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated …

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic …

T Shi, DA McAllister, KL O'Brien, EAF Simoes… - The Lancet, 2017 - thelancet.com
Background We have previously estimated that respiratory syncytial virus (RSV) was
associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) …

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the …

C Troeger, M Forouzanfar, PC Rao, I Khalil… - The Lancet Infectious …, 2017 - thelancet.com
Summary Background The Global Burden of Diseases, Injuries, and Risk Factors (GBD)
Study 2015 provides an up-to-date analysis of the burden of lower respiratory tract infections …