The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness
Background The poor physical health of people with mental illness is a multifaceted,
transdiagnostic, and global problem. People with mental illness have an increased risk of …
transdiagnostic, and global problem. People with mental illness have an increased risk of …
Smoking cessation for improving mental health
Background There is a common perception that smoking generally helps people to manage
stress, and may be a form of'self‐medication'in people with mental health conditions …
stress, and may be a form of'self‐medication'in people with mental health conditions …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
Minimal phenotyping yields genome-wide association signals of low specificity for major depression
Minimal phenotyping refers to the reliance on the use of a small number of self-reported
items for disease case identification, increasingly used in genome-wide association studies …
items for disease case identification, increasingly used in genome-wide association studies …
Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study
Objectives To investigate the role of body mass index (BMI), systolic blood pressure, and
smoking behaviour in explaining the effect of education on the risk of cardiovascular disease …
smoking behaviour in explaining the effect of education on the risk of cardiovascular disease …
An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
The age of large-scale genome-wide association studies (GWAS) has provided us with an
unprecedented opportunity to evaluate the genetic liability of complex disease using …
unprecedented opportunity to evaluate the genetic liability of complex disease using …
Smoking and stroke: a Mendelian randomization study
We used the Mendelian randomization design to explore the potential causal association of
smoking with ischemic stroke and intracerebral hemorrhage using summary statistics data …
smoking with ischemic stroke and intracerebral hemorrhage using summary statistics data …
Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study
BackgroundThere is increasing evidence that smoking is a risk factor for severe mental
illness, including bipolar disorder. Conversely, patients with bipolar disorder might smoke …
illness, including bipolar disorder. Conversely, patients with bipolar disorder might smoke …
Appraising the role of previously reported risk factors in epithelial ovarian cancer risk: a Mendelian randomization analysis
J Yarmolinsky, CL Relton, A Lophatananon… - PLoS …, 2019 - journals.plos.org
Background Various risk factors have been associated with epithelial ovarian cancer risk in
observational epidemiological studies. However, the causal nature of the risk factors …
observational epidemiological studies. However, the causal nature of the risk factors …
Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization
Attention‐deficit hyperactivity disorder (ADHD) has consistently been associated with
substance use, but the nature of this association is not fully understood. To inform …
substance use, but the nature of this association is not fully understood. To inform …