Addiction is a widespread public health issue with social and economic ramifications.
Substance abuse disorders are often accompanied by disruptions in circadian rhythms …

Alcoholism is a complex psychiatric disorder that has a multifactorial etiology. Epigenetic
mechanisms are uniquely capable of accounting for the multifactorial nature of the disease …

The circadian clock system drives daily rhythms in physiology, metabolism, and behavior in
mammals. Molecular mechanisms of this system consist of multiple clock genes, with …

Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society.
Genetic factors determine up to 60% of an individual's risk of developing problematic alcohol …

Cactophilic Drosophila species provide a valuable model to study gene–environment
interactions and ecological adaptation. Drosophila buzzatii and Drosophila mojavensis are …

Background Despite the profound clinical significance and strong heritability of alcohol use
disorder (AUD), we do not yet have a comprehensive understanding of the naturally …

Alcohol tolerance is a simple form of behavioural and neural plasticity that occurs with the
first drink. Neural plasticity in tolerance is likely a substrate for longer term adaptations that …

It is claimed that a correlation exists between disturbance of circadian rhythms by factors
such as alteration of normal light–dark cycle and the development of addiction. However, the …

Neuropsychiatric disorders are of complex etiology, often including a large genetic
component. In order to help identify and study the molecular and physiological mechanisms …