Cu (I)-catalyzed click chemistry in glycoscience and their diverse applications
Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …
Protein cages: from fundamentals to advanced applications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
Cu-catalyzed click reaction in carbohydrate chemistry
Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …
“click reaction”, serves as the most potent and highly dependable tool for facile construction …
Recent fascinating aspects of the CuAAC click reaction
CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts
as a true click chemistry reaction allowing densely functional molecular fragments to be …
as a true click chemistry reaction allowing densely functional molecular fragments to be …
Virus‐like particles: Next‐generation nanoparticles for targeted therapeutic delivery
MJ Rohovie, M Nagasawa… - … & translational medicine, 2017 - Wiley Online Library
Most drug therapies distribute the agents throughout the entire body, even though the drugs
are typically only needed at specific tissues. This often limits dosage and causes discomfort …
are typically only needed at specific tissues. This often limits dosage and causes discomfort …
Choosing an effective protein bioconjugation strategy
N Stephanopoulos, MB Francis - Nature chemical biology, 2011 - nature.com
The collection of chemical techniques that can be used to attach synthetic groups to proteins
has expanded substantially in recent years. Each of these approaches allows new protein …
has expanded substantially in recent years. Each of these approaches allows new protein …
Copper‐catalyzed azide–alkyne click chemistry for bioconjugation
The copper‐catalyzed azide‐alkyne cycloaddition reaction is widely used for the connection
of molecular entities of all sizes. A protocol is provided here for the process with …
of molecular entities of all sizes. A protocol is provided here for the process with …
Virus-based nanocarriers for drug delivery
Y Ma, RJM Nolte, JJLM Cornelissen - Advanced drug delivery reviews, 2012 - Elsevier
New nanocarrier platforms based on natural biological building blocks offer great promises
in revolutionalizing medicine. The usage of specific protein cage structures: virus-like …
in revolutionalizing medicine. The usage of specific protein cage structures: virus-like …
Micro‐nanocarriers based drug delivery technology for blood‐brain barrier crossing and brain tumor targeting therapy
L Wang, Y Shi, J Jiang, C Li, H Zhang, X Zhang… - Small, 2022 - Wiley Online Library
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …
One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes
JI MacDonald, HK Munch, T Moore… - Nature chemical …, 2015 - nature.com
The chemical modification of proteins is an enabling technology for many scientific fields,
including chemical biology, biophysics, bioengineering and materials science. These …
including chemical biology, biophysics, bioengineering and materials science. These …