[HTML][HTML] The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

[HTML][HTML] Fisetin, a potent anticancer flavonol exhibiting cytotoxic activity against neoplastic malignant cells and cancerous conditions: a scoping, comprehensive …

R Kubina, K Krzykawski, A Kabała-Dzik, RD Wojtyczka… - Nutrients, 2022 - mdpi.com
Diet plays a crucial role in homeostasis maintenance. Plants and spices containing
flavonoids have been widely used in traditional medicine for thousands of years. Flavonols …

[HTML][HTML] The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products

JP Shiau, YT Chuang, JY Tang, KH Yang, FR Chang… - Antioxidants, 2022 - mdpi.com
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

[HTML][HTML] Targeting cancer stem cells by dietary agents: an important therapeutic strategy against human malignancies

M Deldar Abad Paskeh, S Asadi, A Zabolian… - International Journal of …, 2021 - mdpi.com
As a multifactorial disease, treatment of cancer depends on understanding unique
mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for …

[HTML][HTML] Selected flavonols in breast and gynecological cancer: a systematic review

D Wendlocha, K Krzykawski, A Mielczarek-Palacz… - Nutrients, 2023 - mdpi.com
The consumption of foods that are rich in phenolic compounds has chemopreventive effects
on many cancers, including breast cancer, ovarian cancer, and endometrial cancer. A wide …

[HTML][HTML] Fisetin—In search of better bioavailability—From macro to nano modifications: A review

J Szymczak, J Cielecka-Piontek - International Journal of Molecular …, 2023 - mdpi.com
As secondary plant metabolites, polyphenols are abundant in fruits and vegetables. They
are in high demand because of their many health benefits. However, their low bioavailability …

[HTML][HTML] Molecular Mechanisms of Flavonoids against Tumor Gamma-Herpesviruses and Their Correlated Cancers—A Focus on EBV and KSHV Life Cycles and …

STS Hassan, M Šudomová - International Journal of Molecular Sciences, 2022 - mdpi.com
Epstein–Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) are cancer-
causing viruses that belong to human gamma-herpesviruses. They are DNA viruses known …

Phytochemicals for the prevention and treatment of pancreatic cancer: Current progress and future prospects

N Casarcia, P Rogers, E Guld, S Iyer… - British Journal of …, 2023 - Wiley Online Library
Pancreatic cancer is the third leading cause of cancer‐related deaths in the United States,
owing to its aggressive nature and suboptimal treatment options, emphasizing the need for …

Fisetin-loaded grape-derived nanoparticles improve anticancer efficacy in MOLT-4 cells

P Sarvarian, P Samadi, E Gholipour… - Biochemical and …, 2023 - Elsevier
Purpose Fisetin (FIS) is a natural flavonoid with anti-proliferative and anti-apoptotic effects
on different human cancer cell lines and can be considered a therapeutic agent for ALL …

[HTML][HTML] Autophagy as a therapeutic target of natural products enhancing embryo implantation

H Park, M Cho, Y Do, JK Park, SJ Bae, J Joo, KT Ha - Pharmaceuticals, 2021 - mdpi.com
Infertility is an emerging health issue worldwide, and female infertility is intimately
associated with embryo implantation failure. Embryo implantation is an essential process …