Amino acids and its pharmaceutical applications: A mini review

A Bongioanni, MS Bueno, BA Mezzano… - International Journal of …, 2022 - Elsevier
Amino acids are natural compounds that can be safely used in pharmaceutical applications.
Considering the great interest in the amino acids used in the pharmaceutical industry, this …

Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

A Abu-Much, R Darawshi, H Dawud, H Kasem… - Biomaterials …, 2022 - pubs.rsc.org
Transdermal drug delivery systems are a useful and minimally invasive alternative to other
drug administration routes. Biodegradable polymeric microneedles (MNs) are widely used in …

Development and Characterization of Eudragit®-Based Electrospun Nanofibrous Mats and Their Formulation into Nanofiber Tablets for the Modified Release of …

M Vlachou, S Kikionis, A Siamidi, S Kyriakou, A Tsotinis… - Pharmaceutics, 2019 - mdpi.com
Furosemide, a chloride channel blocker ordinarily used as a high-ceiling or loop diuretic, is
practically insoluble in water and dilute acids. Due to its acidic nature, furosemide is mostly …

Carbon quantum dots embedded silica molecular imprinted polymer as a novel and sensitive fluorescent nanoprobe for reproducible enantioselective quantification of …

Z Dehghani, M Akhond, G Absalan - Microchemical Journal, 2021 - Elsevier
The nanoparticles of carbon quantum dots embedded silica molecular imprinted polymer
(CQDs-SiO 2@ MIP) were utilized as novel, sensitive, repeatable, and reproducible …

The effect of co-amorphization of glibenclamide on its dissolution properties and permeability through an MDCKII-MDR1 cell layer

H Sormunen, M Ruponen, R Laitinen - International Journal of …, 2019 - Elsevier
Co-amorphous mixtures have been demonstrated to represent a promising approach for
enhancing the dissolution of poorly water-soluble drugs. However, little is known of their …

Co-amorphous formulations of furosemide with arginine and p-glycoprotein inhibitor drugs

M Ruponen, K Kettunen, M Santiago Pires, R Laitinen - Pharmaceutics, 2021 - mdpi.com
In this study, the amino acid arginine (ARG) and P-glycoprotein (P-gp) inhibitors verapamil
hydrochloride (VER), piperine (PIP) and quercetin (QRT) were used as co-formers for co …

Furosemide: Triethanolamine salt as a strategy to improve the biopharmaceutical properties and photostability of the drug

J Abraham Miranda, C Garnero, AK Chattah… - Crystal Growth & …, 2019 - ACS Publications
With the purpose of enhancing the biopharmaceutical properties of the furosemide, a
pharmaceutical salt was obtained and characterized by combining the drug and …

Design and evaluation of multicomponent systems as a potential strategy to enhance the pharmaceutical performance of albendazole desmotropes

A Bongioanni, BA Mezzano, MR Longhi… - European Journal of …, 2024 - Elsevier
Albendazole, an anthelmintic recognized by the World Health Organization as an essential
medicine, is known to have limitations in solubility and bioavailability. To improve these …

Co-amorphization story of furosemide-amino acid systems: protonation and aromatic stacking insights for promoting compatibility and stability

M Li, M Wang, Y Liu, R Ouyang, M Liu… - Crystal Growth & …, 2021 - ACS Publications
Furosemide (FUR) is usually used to treat congestive heart failure and edema. Although
bioavailability problems exist due to its poor solubility and unstable gastrointestinal …

Improved Activity of Rifampicin Against Biofilms of Staphylococcus aureus by Multicomponent Complexation

AV Dan Córdoba, V Aiassa, MR Longhi… - AAPS …, 2020 - Springer
The aim of this study was to evaluate a multicomponent complex (MC) between rifampicin
(RIF), β-cyclodextrin (β-CD), and selected amino acids to enhance the solubility and …